n-(5-Acetyl-2-hydroxyphenyl)acetamide

Base Information

• Chemical Name: n-(5-Acetyl-2-hydroxyphenyl)acetamide
• CAS No.: 74896-30-3
• Molecular Formula: C10H11NO3
• Molecular Weight: 193.202
• NSC Number: 139140
• DSSTox Substance ID: DTXSID10996389
• Wikidata: Q82988151
• Mol file: 74896-30-3.mol

Synonyms:74896-30-3;n-(5-acetyl-2-hydroxyphenyl)acetamide;NSC139140;SCHEMBL1544846;DTXSID10996389;GXAIOAIGWKRNIF-UHFFFAOYSA-N;STK925961;AKOS005651992;NSC-139140;N-(5-Acetyl-2-hydroxy-phenyl)-acetamide;1-[3-acetylamino-4-hydroxyphenyl]ethanone;1-[3-acetylamino-4-hydroxyphenyl] ethanone;N-(5-Acetyl-2-hydroxyphenyl)ethanimidic acid

Chemical Property of n-(5-Acetyl-2-hydroxyphenyl)acetamide

Chemical Property:

• Vapor Pressure: 1.44E-08mmHg at 25°C
• Boiling Point: 446°C at 760 mmHg
• Flash Point: 223.5°C
• Density: 1.267g/cm³
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 193.07389321
• Heavy Atom Count: 14
• Complexity: 240

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(=O)C1=CC(=C(C=C1)O)NC(=O)C

Technology Process of n-(5-Acetyl-2-hydroxyphenyl)acetamide

There total 6 articles about n-(5-Acetyl-2-hydroxyphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

3-amino-4-hydroxyacetophenone (54255-50-4) + acetic anhydride (108-24-7) → 1-<3-(acetylamino)-4-hydroxyphenyl>ethanone (74896-30-3)

Guidance literature:

With acetic acid; at 60 ℃; for 1h;

DOI:10.1080/00304948.2015.1005987

Reference yield: 85.0%

4'-hydroxy-3'-nitroacetophenone (6322-56-1) + acetic anhydride (108-24-7) → 1-<3-(acetylamino)-4-hydroxyphenyl>ethanone (74896-30-3)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; DMF (N,N-dimethyl-formamide); for 2h; under 1551.49 Torr;

Reference yield:

acetyl chloride (75-36-5) + 2-(acetylamino)phenol (614-80-2) → 1-<3-(acetylamino)-4-hydroxyphenyl>ethanone (74896-30-3)

Guidance literature:

With aluminium trichloride; N,N-dimethyl-formamide; at 85 ℃; for 5h;

DOI:10.1055/s-1990-26979

upstream raw materials:

2-acetamidophenyl acetate

acetyl chloride

2-(acetylamino)phenol

3-amino-4-hydroxyacetophenone

Downstream raw materials:

3-amino-4-hydroxyacetophenone

1-<3-(acetylamino)-4-(3-chloropropoxy)phenyl>ethanone

1-(5-acetamido-4-ethoxy-2-nitrophenyl)ethanone

N-(3-cyano-7-ethoxy-4-oxo-1,4-dihydroquinolin-6-yl)acetamide