1-benzoyl-4-benzamido-1,2,2a,3,4,5-hexahydro-5-<2-methyl-3-((methylsulfonyl)oxy)propylidene>benzindole

Base Information

Chemical Name:1-benzoyl-4-benzamido-1,2,2a,3,4,5-hexahydro-5-<2-methyl-3-((methylsulfonyl)oxy)propylidene>benzindole
CAS No.:82359-57-7
Molecular Formula:C₃₀H₃₀N₂O₅S
Molecular Weight:530.645
Hs Code.:

1-benzoyl-4-benzamido-1,2,2a,3,4,5-hexahydro-5-<2-methyl-3-((methylsulfonyl)oxy)propylidene>benz<cd>indole

Synonyms:1-benzoyl-4-benzamido-1,2,2a,3,4,5-hexahydro-5-<2-methyl-3-((methylsulfonyl)oxy)propylidene>benzindole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-benzoyl-4-benzamido-1,2,2a,3,4,5-hexahydro-5-<2-methyl-3-((methylsulfonyl)oxy)propylidene>benzindole

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Technology Process of 1-benzoyl-4-benzamido-1,2,2a,3,4,5-hexahydro-5-<2-methyl-3-((methylsulfonyl)oxy)propylidene>benzindole

There total 6 articles about 1-benzoyl-4-benzamido-1,2,2a,3,4,5-hexahydro-5-<2-methyl-3-((methylsulfonyl)oxy)propylidene>benzindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 82359-56-6,88668-87-5
1-benzoyl-4-benzamido-1,2,2a,3,4,5-hexahydro-5-hydroxy-5-(3-hydroxy-2-methylpropyl)benzindole

: 124-63-0
methanesulfonyl chloride

: 82359-57-7
1-benzoyl-4-benzamido-1,2,2a,3,4,5-hexahydro-5-<2-methyl-3-((methylsulfonyl)oxy)propylidene>benzindole

: 88636-14-0
Methanesulfonic acid (R)-3-((S)-1-benzoyl-4-benzoylamino-1,2,2a,3-tetrahydro-benzo[cd]indol-5-yl)-2-methyl-propyl ester

: 88636-15-1
Methanesulfonic acid (S)-3-((2aR,4S,5R)-1-benzoyl-4-benzoylamino-5-hydroxy-1,2,2a,3,4,5-hexahydro-benzo[cd]indol-5-yl)-2-methyl-propyl ester

Guidance literature:: With triethylamine; In tetrahydrofuran; -10 deg C, 30 min, r.t., 1 h;
DOI:10.1021/ja00318a044

Reference yield:

: 74606-93-2
1-benzoyl-4-benzamido-1,2,2a,3,4,5-hexahydro-5-hydroxy-α-methylenebenzindole-5-propionic acid, γ-lactone

: 82359-57-7
1-benzoyl-4-benzamido-1,2,2a,3,4,5-hexahydro-5-<2-methyl-3-((methylsulfonyl)oxy)propylidene>benzindole

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) sodium borohydride; 2.) benzoyl chloride, pyridine / 1.) methanol, r.t., 2 h; 2.) methanol, 0 deg C

2: 30 percent / triethylamine / tetrahydrofuran / -10 deg C, 30 min, r.t., 1 h

With pyridine; sodium tetrahydroborate; benzoyl chloride; triethylamine; In tetrahydrofuran;
DOI:10.1021/ja00318a044

Reference yield:

: 74644-93-2
1-benzoyl-4-benzamido-5-oxo-1,2,2a,3,4,5-hexahydrobenzindole

: 82359-57-7
1-benzoyl-4-benzamido-1,2,2a,3,4,5-hexahydro-5-<2-methyl-3-((methylsulfonyl)oxy)propylidene>benzindole

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / Zn / I₂ / tetrahydrofuran / 14 h / 50 °C

2: 1.) sodium borohydride; 2.) benzoyl chloride, pyridine / 1.) methanol, r.t., 2 h; 2.) methanol, 0 deg C

3: 30 percent / triethylamine / tetrahydrofuran / -10 deg C, 30 min, r.t., 1 h

With pyridine; sodium tetrahydroborate; benzoyl chloride; triethylamine; zinc; iodine; In tetrahydrofuran;
DOI:10.1021/ja00318a044