Methanesulfonic acid (1R,2R)-2-(tert-butyl-diphenyl-silanyloxymethyl)-cyclopropylmethyl ester

Base Information

• Chemical Name: Methanesulfonic acid (1R,2R)-2-(tert-butyl-diphenyl-silanyloxymethyl)-cyclopropylmethyl ester
• CAS No.: 1026675-20-6
• Molecular Formula: C₂₂H₃₀O₄SSi
• Molecular Weight: 418.629
• Mol file: 1026675-20-6.mol

Synonyms:Methanesulfonic acid (1R,2R)-2-(tert-butyl-diphenyl-silanyloxymethyl)-cyclopropylmethyl ester

Chemical Property of Methanesulfonic acid (1R,2R)-2-(tert-butyl-diphenyl-silanyloxymethyl)-cyclopropylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methanesulfonic acid (1R,2R)-2-(tert-butyl-diphenyl-silanyloxymethyl)-cyclopropylmethyl ester

There total 5 articles about Methanesulfonic acid (1R,2R)-2-(tert-butyl-diphenyl-silanyloxymethyl)-cyclopropylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanesulfonyl chloride (124-63-0) + (1R,2R)-2-<<(tert-Butyldiphenylsilyl)oxy>methyl>-1-(hydroxymethyl)cyclopropane (154001-59-9) → Methanesulfonic acid (1R,2R)-2-(tert-butyl-diphenyl-silanyloxymethyl)-cyclopropylmethyl ester (1026675-20-6)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 2h;

DOI:10.1021/jo00080a017

Reference yield:

(1E,4'S)-3-[(tert-Butyldiphenylsilyl)oxy]-1-(2',2'-dimethyl-1',3'-dioxolan-4'-yl)-1-propene (154001-54-4) → Methanesulfonic acid (1R,2R)-2-(tert-butyl-diphenyl-silanyloxymethyl)-cyclopropylmethyl ester (1026675-20-6)

Guidance literature:

Multi-step reaction with 5 steps

1: diethylzinc / dichloromethane / 12 h / -23 - 0 °C

2: pyridinium p-toluenesulfonate / methanol / 5 h / Ambient temperature

3: sodium periodate / tetrahydrofuran; water / 0 °C

4: sodium tetrahydroborate / methanol / 0 °C

5: triethylamine / dichloromethane / 2 h / 0 °C

With sodium tetrahydroborate; sodium periodate; diethylzinc; pyridinium p-toluenesulfonate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water;

DOI:10.1021/jo00080a017

Reference yield:

(1R,2R)-2-(tert-butyldiphenylsilyloxy)methyl-1-formylcyclopropane (408348-31-2) → Methanesulfonic acid (1R,2R)-2-(tert-butyl-diphenyl-silanyloxymethyl)-cyclopropylmethyl ester (1026675-20-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / methanol / 0 °C

2: triethylamine / dichloromethane / 2 h / 0 °C

With sodium tetrahydroborate; triethylamine; In methanol; dichloromethane;

DOI:10.1021/jo00080a017

upstream raw materials:

methanesulfonyl chloride

(1R,2R)-2-<<(tert-Butyldiphenylsilyl)oxy>methyl>-1-(hydroxymethyl)cyclopropane

(1E,4'S)-3-[(tert-Butyldiphenylsilyl)oxy]-1-(2',2'-dimethyl-1',3'-dioxolan-4'-yl)-1-propene

(1R,2R)-2-(tert-butyldiphenylsilyloxy)methyl-1-formylcyclopropane

Downstream raw materials:

((1R,2R)-2-Hydroxymethyl-cyclopropylmethyl)-carbamic acid tert-butyl ester

[(1R,2R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-cyclopropylmethyl]-carbamic acid tert-butyl ester

(2-(((tert-butyldiphenylsilyl)oxy)methyl)cyclopropyl)methanamine

(1R,2R)-1-<methyl>-2-carboxycyclopropane