(1S,4R)-2-[(2R,4S)-5-tert-Butoxy-2,4-dimethyl-pent-(E)-ylidene]-1-isopropyl-4-methyl-cyclohexane

Base Information

Chemical Name:(1S,4R)-2-[(2R,4S)-5-tert-Butoxy-2,4-dimethyl-pent-(E)-ylidene]-1-isopropyl-4-methyl-cyclohexane
CAS No.:693833-32-8
Molecular Formula:C₂₁H₄₀O
Molecular Weight:308.548
Hs Code.:

Synonyms:(1S,4R)-2-[(2R,4S)-5-tert-Butoxy-2,4-dimethyl-pent-(E)-ylidene]-1-isopropyl-4-methyl-cyclohexane

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Chemical Property of (1S,4R)-2-[(2R,4S)-5-tert-Butoxy-2,4-dimethyl-pent-(E)-ylidene]-1-isopropyl-4-methyl-cyclohexane

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Technology Process of (1S,4R)-2-[(2R,4S)-5-tert-Butoxy-2,4-dimethyl-pent-(E)-ylidene]-1-isopropyl-4-methyl-cyclohexane

There total 11 articles about (1S,4R)-2-[(2R,4S)-5-tert-Butoxy-2,4-dimethyl-pent-(E)-ylidene]-1-isopropyl-4-methyl-cyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: Acetic acid (1R,2S,5R)-2-isopropyl-5-methyl-1-((E)-propenyl)-cyclohexyl ester

: 130432-77-8
(2R)-2-Methyl-3-t-butoxy-1-iodopropane

: 693833-32-8
(1S,4R)-2-[(2R,4S)-5-tert-Butoxy-2,4-dimethyl-pent-(E)-ylidene]-1-isopropyl-4-methyl-cyclohexane

Guidance literature:: (2R)-2-Methyl-3-t-butoxy-1-iodopropane; With tert.-butyl lithium; In diethyl ether; at -78 - 0 ℃; for 1.5h;

In tetrahydrofuran; diethyl ether; at -78 ℃; for 2h;

Acetic acid (1R,2S,5R)-2-isopropyl-5-methyl-1-((E)-propenyl)-cyclohexyl ester; In tetrahydrofuran; diethyl ether; at -50 - 20 ℃; for 17h;
DOI:10.1139/v03-182

Reference yield:

: 693833-46-4
1-tert-butoxy-3-iodo-2-methyl-propane

: Acetic acid (1S,2R,5S)-2-isopropyl-5-methyl-1-((E)-propenyl)-cyclohexyl ester

: 693833-32-8
(1S,4R)-2-[(2R,4S)-5-tert-Butoxy-2,4-dimethyl-pent-(E)-ylidene]-1-isopropyl-4-methyl-cyclohexane

: 693833-45-3
(1S,4R)-2-[(2R,4R)-5-tert-Butoxy-2,4-dimethyl-pent-(E)-ylidene]-1-isopropyl-4-methyl-cyclohexane

Guidance literature:: 1-tert-butoxy-3-iodo-2-methyl-propane; With tert.-butyl lithium; In diethyl ether; at -78 - 0 ℃; for 1.5h;

In tetrahydrofuran; diethyl ether; at -78 ℃; for 2h;

Acetic acid (1S,2R,5S)-2-isopropyl-5-methyl-1-((E)-propenyl)-cyclohexyl ester; In tetrahydrofuran; diethyl ether; at -50 - 20 ℃; for 17h;
DOI:10.1139/v03-182

Reference yield:

: (1R,2S,5R)-2-Isopropyl-5-methyl-1-((E)-propenyl)-cyclohexanol

: 693833-32-8
(1S,4R)-2-[(2R,4S)-5-tert-Butoxy-2,4-dimethyl-pent-(E)-ylidene]-1-isopropyl-4-methyl-cyclohexane

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi

2.1: t-BuLi / diethyl ether / 1.5 h / -78 - 0 °C

2.2: CuCN / tetrahydrofuran; diethyl ether / 2 h / -78 °C

2.3: tetrahydrofuran; diethyl ether / 17 h / -50 - 20 °C

With n-butyllithium; tert.-butyl lithium; In diethyl ether;
DOI:10.1139/v03-182