(1S,4R)-2-[(S)-3-tert-Butoxy-2-methyl-prop-(E)-ylidene]-1-isopropyl-4-methyl-cyclohexane

Base Information

Chemical Name:(1S,4R)-2-[(S)-3-tert-Butoxy-2-methyl-prop-(E)-ylidene]-1-isopropyl-4-methyl-cyclohexane
CAS No.:693833-30-6
Molecular Formula:C₁₈H₃₄O
Molecular Weight:266.467
Hs Code.:

Synonyms:(1S,4R)-2-[(S)-3-tert-Butoxy-2-methyl-prop-(E)-ylidene]-1-isopropyl-4-methyl-cyclohexane

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Chemical Property of (1S,4R)-2-[(S)-3-tert-Butoxy-2-methyl-prop-(E)-ylidene]-1-isopropyl-4-methyl-cyclohexane

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Technology Process of (1S,4R)-2-[(S)-3-tert-Butoxy-2-methyl-prop-(E)-ylidene]-1-isopropyl-4-methyl-cyclohexane

There total 3 articles about (1S,4R)-2-[(S)-3-tert-Butoxy-2-methyl-prop-(E)-ylidene]-1-isopropyl-4-methyl-cyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: Acetic acid (1R,2S,5R)-2-isopropyl-5-methyl-1-((E)-propenyl)-cyclohexyl ester

: 1634-04-4
tert-butyl methyl ether

: 693833-30-6
(1S,4R)-2-[(S)-3-tert-Butoxy-2-methyl-prop-(E)-ylidene]-1-isopropyl-4-methyl-cyclohexane

Guidance literature:: tert-butyl methyl ether; With potassium tert-butylate; sec.-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 2.5h;

Acetic acid (1R,2S,5R)-2-isopropyl-5-methyl-1-((E)-propenyl)-cyclohexyl ester; With lithium bromide; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 18h;
DOI:10.1139/v03-182

Reference yield:

: 10458-14-7,14073-97-3,17627-49-5,7786-64-3
(2R,5S)-menthone

: 693833-30-6
(1S,4R)-2-[(S)-3-tert-Butoxy-2-methyl-prop-(E)-ylidene]-1-isopropyl-4-methyl-cyclohexane

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran

2.1: n-BuLi

3.1: t-BuOK; s-BuLi / tetrahydrofuran; hexane / 2.5 h / -78 °C

3.2: 92 percent / CuCN; LiBr / tetrahydrofuran; hexane / 18 h / -78 - 20 °C

With n-butyllithium; potassium tert-butylate; sec.-butyllithium; In tetrahydrofuran; hexane;
DOI:10.1139/v03-182

Reference yield:

: 83803-22-9
(1S,2S,5R)-2-isopropyl-5-methyl-1-{1-propen-1-yl}cyclohexan-1-ol

: 693833-30-6
(1S,4R)-2-[(S)-3-tert-Butoxy-2-methyl-prop-(E)-ylidene]-1-isopropyl-4-methyl-cyclohexane

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi

2.1: t-BuOK; s-BuLi / tetrahydrofuran; hexane / 2.5 h / -78 °C

2.2: 92 percent / CuCN; LiBr / tetrahydrofuran; hexane / 18 h / -78 - 20 °C

With n-butyllithium; potassium tert-butylate; sec.-butyllithium; In tetrahydrofuran; hexane;
DOI:10.1139/v03-182