(3R,4S)-1-{5-[1-(5-chloropyrimidin-2-yl)-4-methoxypiperidin-4-ylmethoxy]pyrimidin-2-yl}-4-(2,4,5-trifluorophenyl)pyrrolidin-3-ylamine

Base Information

Chemical Name:(3R,4S)-1-{5-[1-(5-chloropyrimidin-2-yl)-4-methoxypiperidin-4-ylmethoxy]pyrimidin-2-yl}-4-(2,4,5-trifluorophenyl)pyrrolidin-3-ylamine
CAS No.:1351338-68-5
Molecular Formula:C₂₅H₂₇ClF₃N₇O₂
Molecular Weight:549.983
Hs Code.:

Synonyms:(3R,4S)-1-{5-[1-(5-chloropyrimidin-2-yl)-4-methoxypiperidin-4-ylmethoxy]pyrimidin-2-yl}-4-(2,4,5-trifluorophenyl)pyrrolidin-3-ylamine

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Chemical Property of (3R,4S)-1-{5-[1-(5-chloropyrimidin-2-yl)-4-methoxypiperidin-4-ylmethoxy]pyrimidin-2-yl}-4-(2,4,5-trifluorophenyl)pyrrolidin-3-ylamine

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Technology Process of (3R,4S)-1-{5-[1-(5-chloropyrimidin-2-yl)-4-methoxypiperidin-4-ylmethoxy]pyrimidin-2-yl}-4-(2,4,5-trifluorophenyl)pyrrolidin-3-ylamine

There total 8 articles about (3R,4S)-1-{5-[1-(5-chloropyrimidin-2-yl)-4-methoxypiperidin-4-ylmethoxy]pyrimidin-2-yl}-4-(2,4,5-trifluorophenyl)pyrrolidin-3-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1351341-88-2
[(3R,4S)-1-{5-[1-(5-chloropyrimidin-2-yl)-4-methoxypiperidin-4-ylmethoxy]pyrimidin-2-yl}-4-(2,4,5-trifluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester

: 1351338-68-5
(3R,4S)-1-{5-[1-(5-chloropyrimidin-2-yl)-4-methoxypiperidin-4-ylmethoxy]pyrimidin-2-yl}-4-(2,4,5-trifluorophenyl)pyrrolidin-3-ylamine

Guidance literature:: [(3R,4S)-1-{5-[1-(5-chloropyrimidin-2-yl)-4-methoxypiperidin-4-ylmethoxy]pyrimidin-2-yl}-4-(2,4,5-trifluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 16h;

With ammonium hydroxide; In methanol; dichloromethane;

Reference yield:

: 915100-83-3
[(3R,4S)-4-(2,4,5-trifluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester

: 1351338-68-5
(3R,4S)-1-{5-[1-(5-chloropyrimidin-2-yl)-4-methoxypiperidin-4-ylmethoxy]pyrimidin-2-yl}-4-(2,4,5-trifluorophenyl)pyrrolidin-3-ylamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 4 h / 150 °C / microwave irradiation

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 1 h / Inert atmosphere

3.1: PS-triphenylphosphine / tetrahydrofuran / 0.08 h / 20 °C

3.2: 0.08 h / 20 °C

3.3: 64 h / 20 - 40 °C

4.1: trifluoroacetic acid / dichloromethane / 16 h / 20 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;

Reference yield:

: [(trans)-4-(2,4,5-trifluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester

: 1351338-68-5
(3R,4S)-1-{5-[1-(5-chloropyrimidin-2-yl)-4-methoxypiperidin-4-ylmethoxy]pyrimidin-2-yl}-4-(2,4,5-trifluorophenyl)pyrrolidin-3-ylamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: (2S)-2-(6-methoxy(2-naphthyl))propanoic acid / ethanol / 20 °C / Reflux

2.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 4 h / 150 °C / microwave irradiation

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 1 h / Inert atmosphere

4.1: PS-triphenylphosphine / tetrahydrofuran / 0.08 h / 20 °C

4.2: 0.08 h / 20 °C

4.3: 64 h / 20 - 40 °C

5.1: trifluoroacetic acid / dichloromethane / 16 h / 20 °C

With hydrogen; (2S)-2-(6-methoxy(2-naphthyl))propanoic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;