915100-83-3

Basic information

• Product Name: [(3R,4S)-4-(2,4,5-trifluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester
• Synonyms: [(3R,4S)-4-(2,4,5-trifluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester
• CAS NO: 915100-83-3
• Molecular Formula: C₁₅H₁₉F₃N₂O₂
• Molecular Weight: 316.3187696
• Mol File: 915100-83-3.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: [(3R,4S)-4-(2,4,5-trifluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [(3R,4S)-4-(2,4,5-trifluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester(915100-83-3)
• EPA Substance Registry System: [(3R,4S)-4-(2,4,5-trifluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester(915100-83-3)

Safety Data

• Hazardous Substances Data: 915100-83-3(Hazardous Substances Data)

Usage

General Description

[(3R,4S)-4-(2,4,5-trifluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester is a chemical compound with the molecular formula C15H20F3NO2. It is a pyrrolidine derivative that consists of a pyrrolidine ring with a trifluorophenyl substituent attached to the nitrogen atom and a carbamic acid tert-butyl ester group. [(3R,4S)-4-(2,4,5-trifluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester is commonly used as a precursor in the synthesis of various pharmaceuticals and agrochemicals due to its versatile reactivity and ability to undergo a wide range of chemical transformations. It has been studied for its potential application as an antifungal and anesthetic agent, as well as its role in medicinal chemistry research. Additionally, it is important to handle this chemical with caution and adhere to proper safety protocols when working with it in laboratory settings, as it may pose health and environmental risks if not managed properly.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 936251-01-3 [(trans)-1-benzyl-4-(2,4,5-trifluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester 
• 936251-05-7 C₁₇H₁₅F₃N₂O₂ 
• 165047-24-5 2,4,5-trifluorobenzaldehyde 
• 956924-25-7 2-nitro-1-(2,4,5-trifluorophenyl)ethanol 
• 936251-01-3 [trans-1-benzyl-4-(2,4,5-trifluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester 
• 915100-66-2 (E)-1,2,4-trifluoro-5-(2-nitrovinyl)benzene 

Downstream Products

• 915100-75-3 tert-butyl (3R,4S)-4-(2,4,5-trifluorophenyl)-1-(6-chloropyrimidin-4-yl)pyrrolidin-3-ylcarbamate 
• 1245079-69-9 4-[(R)-1-(5-{2-[(3R,4S)-3-tert-butoxycarbonylamino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-5-yl}-[1,2,4]oxadiazol-3-yl)ethoxy]piperidine-1-carboxylic acid isopropyl ester 
• 1245507-06-5 [(3R,4S)-1-(5-{(R)-3-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-yl]butoxy}pyrimidin-2-yl)-4-(2,4,5-trifluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester 
• 1245507-28-1 4-((R)-3-{2-[(3R,4S)-3-tert-butoxycarbonylamino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-5-yloxy}-1-methylpropyl)piperidine-1-carboxylic acid isopropyl ester 
• 1351342-38-5 [(3R,4S)-1-{5-[1-(3-ethyl-[1,2,4]oxadiazol-5-yl)piperidin-4-ylmethoxy]pyrimidin-2-yl}-4-(2,4,5-trifluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester 
• 1351345-52-2 [(3R,4S)-1-{5-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-ylmethoxy]pyrimidin-2-yl}-4-(2,4,5-trifluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester 
• 1351338-51-6 (3R,4S)-1-{5-[l-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-ylmethoxy]pyrimidin-2-yl}-4-(2,4,5-trifluorophenyl)pyrrolidin-3-ylamine 
• 1351345-55-5 [(3R,4S)-1-{5-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-ylmethoxy]-4-methylpyrimidin-2-yl}-4-(2,4,5-trifluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester 
• 1351338-59-4 (3R,4S)-1-{5-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-ylmethoxy]-4-methylpyrimidin-2-yl}-4-(2,4,5-trifluorophenyl)pyrrolidin-3-ylamine p-toluenesulfonate 
• 1351341-85-9 [(3R,4S)-1-(5-benzyloxypyrimidin-2-yl)-4-(2,4,5-trifluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester 
• 1351338-68-5 (3R,4S)-1-{5-[1-(5-chloropyrimidin-2-yl)-4-methoxypiperidin-4-ylmethoxy]pyrimidin-2-yl}-4-(2,4,5-trifluorophenyl)pyrrolidin-3-ylamine 
• 1351343-61-7 [(3R,4S)-1-{5-[1-(3-isopropyl-[1,2,4]oxadiazol-5-ylmethyl)azetidin-3-ylmethoxy]pyrimidin-2-yl}-4-(2,4,5-trifluoro-phenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester 
• 1351343-12-8 [(3R,4S)-1-{5-[1-(3-methyl-butyryl)piperidin-4-ylmethoxy]pyrimidin-2-yl}-4-(2,4,5-trifluoro-phenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester 
• 1351343-10-6 [(3R,4S)-1-{5-[1-(3-isopropyl-[1,2,4]oxadiazole-5-carbonyl)piperidin-4-ylmethoxy]pyrimidin-2-yl}-4-(2,4,5-trifluoro-phenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester 

Relevant articles and documents

1,4 DISUBSTITUTED PYRROLIDINE - 3 - YL -AMINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF METABOLIC DISORDERS

Therapeutic compounds are disclosed having the general formula (I) that are useful for the treatment of metabolic disorders, including type II diabetes. The compounds have activity as agonists of GPR1 19. Compounds having stereochemistry of formula (la) may also demonstrate DPP-IV inhibitory activity.

CYCLOAMINO DERIVATIVES AS GPR119 ANTAGONISTS

Therapeutic compounds are disclosed having the general formula (I) that are useful for the treatment of metabolic disorders, including type II diabetes. The compounds have activity as agonists of GPR119. Compounds having the stereochemistry of formula (la) may also demonstrate DPP-IV inhibitory activity.

COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS

The present invention is directed to therapeutic compounds which have activity as agonists of GPR119 and are useful for the treatment of metabolic disorders including type II diabetes.