3'-({[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}methyl)-5-fluorobiphenyl-3-carboxylic acid

Base Information

Chemical Name:3'-({[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}methyl)-5-fluorobiphenyl-3-carboxylic acid
CAS No.:1379541-44-2
Molecular Formula:C₂₅H₂₃BrFN₃O₃
Molecular Weight:512.378
Hs Code.:

Synonyms:3'-({[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}methyl)-5-fluorobiphenyl-3-carboxylic acid

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Chemical Property of 3'-({[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}methyl)-5-fluorobiphenyl-3-carboxylic acid

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Technology Process of 3'-({[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}methyl)-5-fluorobiphenyl-3-carboxylic acid

There total 12 articles about 3'-({[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}methyl)-5-fluorobiphenyl-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 176548-70-2
3-bromo-5-fluorobenzoic acid

: 1379545-29-5
[3-({[4-bromo-1-(2,2-dimethylpropyl)-1H-1,2,3-benzotriazol-5-yl]oxy}methyl)phenyl]boronic acid

: 1379541-44-2
3'-({[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}methyl)-5-fluorobiphenyl-3-carboxylic acid

Guidance literature:: With caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; at 150 ℃; for 0.166667h; Microwave irradiation;

Reference yield:

: 369-36-8
6-fluoro-3-nitroaniline

: 1379541-44-2
3'-({[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}methyl)-5-fluorobiphenyl-3-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: dimethyl sulfoxide / 48 h / 120 °C

1.2: 0.33 h / 20 °C

1.3: pH 7

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 5 h / 20 °C / 760.05 Torr / Inert atmosphere

3.1: sodium nitrite; sulfuric acid / water / 0.83 h / 20 - 120 °C / Microwave irradiation

4.1: pyridinium hydrobromide perbromide / chloroform / 20 °C

4.2: pH 7

5.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C

6.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 0.17 h / 150 °C / Microwave irradiation

With pyridinium hydrobromide perbromide; sulfuric acid; hydrogen; caesium carbonate; sodium nitrite; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In 1,4-dioxane; ethanol; chloroform; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 908288-73-3
1-(2,2-dimethylpropyl)-1H-1,2,3-benzotriazol-5-ol

: 1379541-44-2
3'-({[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}methyl)-5-fluorobiphenyl-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridinium hydrobromide perbromide / chloroform / 20 °C

1.2: pH 7

2.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C

3.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 0.17 h / 150 °C / Microwave irradiation

With pyridinium hydrobromide perbromide; caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; chloroform; water; N,N-dimethyl-formamide;