(1R,2R)-1,2-diphenyl-1-(tert-butyldimethylsilyloxy)-5-(p-toluenesulfonyloxy)-3-oxapentane

Base Information

Chemical Name:(1R,2R)-1,2-diphenyl-1-(tert-butyldimethylsilyloxy)-5-(p-toluenesulfonyloxy)-3-oxapentane
CAS No.:147252-99-1
Molecular Formula:C₂₉H₃₈O₅SSi
Molecular Weight:526.769
Hs Code.:

Synonyms:(1R,2R)-1,2-diphenyl-1-(tert-butyldimethylsilyloxy)-5-(p-toluenesulfonyloxy)-3-oxapentane

Suppliers and Price of (1R,2R)-1,2-diphenyl-1-(tert-butyldimethylsilyloxy)-5-(p-toluenesulfonyloxy)-3-oxapentane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1R,2R)-1,2-diphenyl-1-(tert-butyldimethylsilyloxy)-5-(p-toluenesulfonyloxy)-3-oxapentane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1R,2R)-1,2-diphenyl-1-(tert-butyldimethylsilyloxy)-5-(p-toluenesulfonyloxy)-3-oxapentane

There total 5 articles about (1R,2R)-1,2-diphenyl-1-(tert-butyldimethylsilyloxy)-5-(p-toluenesulfonyloxy)-3-oxapentane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 147252-98-0
(4R,5R)-4,5-diphenyl-3-oxa-5-(tert-butyldimethylsilyloxy)-1-pentanol

: 98-59-9
p-toluenesulfonyl chloride

: 147252-99-1
(1R,2R)-1,2-diphenyl-1-(tert-butyldimethylsilyloxy)-5-(p-toluenesulfonyloxy)-3-oxapentane

Guidance literature:: With pyridine; In dichloromethane; 1) 0 deg C, 2 h, 2) 25 deg C, 2 h;
DOI:10.1055/s-1993-25818

Reference yield:

: 52340-78-0
(R,R)-hydroxybenzoin

: 147252-99-1
(1R,2R)-1,2-diphenyl-1-(tert-butyldimethylsilyloxy)-5-(p-toluenesulfonyloxy)-3-oxapentane

Guidance literature:: Multi-step reaction with 5 steps

1: 94 percent / imidazole / dimethylformamide / 24 h / 20 °C

2: 90 percent / NaH, oil / tetrahydrofuran / 1) 25 deg C, 12 h, 2) 40 deg C, 2 h

3: OsO₄, NaIO₄ / tetrahydrofuran; H₂O / 6 h / 20 °C

4: NaBH₄ / CH₂Cl₂; methanol / 4 h / 5 °C

5: 88 percent / pyridine / CH₂Cl₂ / 1) 0 deg C, 2 h, 2) 25 deg C, 2 h

With pyridine; 1H-imidazole; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; sodium hydride; oil; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1055/s-1993-25818

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 147252-99-1
(1R,2R)-1,2-diphenyl-1-(tert-butyldimethylsilyloxy)-5-(p-toluenesulfonyloxy)-3-oxapentane

Guidance literature:: Multi-step reaction with 5 steps

1: 94 percent / imidazole / dimethylformamide / 24 h / 20 °C

2: 90 percent / NaH, oil / tetrahydrofuran / 1) 25 deg C, 12 h, 2) 40 deg C, 2 h

3: OsO₄, NaIO₄ / tetrahydrofuran; H₂O / 6 h / 20 °C

4: NaBH₄ / CH₂Cl₂; methanol / 4 h / 5 °C

5: 88 percent / pyridine / CH₂Cl₂ / 1) 0 deg C, 2 h, 2) 25 deg C, 2 h

With pyridine; 1H-imidazole; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; sodium hydride; oil; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1055/s-1993-25818