ethyl (S)-2-methoxy-3-(4-hydroxyphenyl)propanoate

Base Information

• Chemical Name: ethyl (S)-2-methoxy-3-(4-hydroxyphenyl)propanoate
• CAS No.: 477979-20-7
• Molecular Formula: C₁₂H₁₆O₄
• Molecular Weight: 224.257
• Mol file: 477979-20-7.mol

Synonyms:ethyl (S)-2-methoxy-3-(4-hydroxyphenyl)propanoate

Chemical Property of ethyl (S)-2-methoxy-3-(4-hydroxyphenyl)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl (S)-2-methoxy-3-(4-hydroxyphenyl)propanoate

There total 8 articles about ethyl (S)-2-methoxy-3-(4-hydroxyphenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

ethanol (64-17-5) + (2S)-3-(4-hydroxyphenyl)-2-methoxypropanoic acid (477980-43-1) → ethyl (S)-2-methoxy-3-(4-hydroxyphenyl)propanoate (477979-20-7)

Guidance literature:

With sulfuric acid; for 4h; enantioselective reaction; Reflux;

DOI:10.1016/j.tetlet.2016.06.093

Reference yield:

(2S)-3-(4-hydroxyphenyl)-2-methoxypropanoic acid (477980-43-1) → ethyl (S)-2-methoxy-3-(4-hydroxyphenyl)propanoate (477979-20-7)

Guidance literature:

With ethanol; sulfuric acid; at 20 ℃;

Reference yield:

p-benzyloxybenzaldehyde (4397-53-9) → ethyl (S)-2-methoxy-3-(4-hydroxyphenyl)propanoate (477979-20-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: NaN(SiMe₃)2

1.2: (CF₃CO)2O

1.3: H₂ / Pd/C

2.1: cross-linked enzyme crystal; MTBE; KH₂PO₄

2.2: 27 percent / (-)-cinchonidine

3.1: 80 percent / H₂SO₄

With potassium dihydrogenphosphate; tert-butyl methyl ether; cross-linked enzyme crystal; sulfuric acid; sodium hexamethyldisilazane;

DOI:10.2533/chimia.2006.580

upstream raw materials:

ethanol

(2S)-3-(4-hydroxyphenyl)-2-methoxypropanoic acid

p-benzyloxybenzaldehyde

(S)-methyl 3-(4-hydroxyphenyl)-2-methoxypropanoate

Downstream raw materials:

ethyl (S)-2-methoxy-3-(4-methoxyphenyl)propanoate

(2S)-3-[4-(1-tert-butoxycarbonyl-1-methyl-ethoxy)-phenyl]-2-methoxypropionic acid ethyl ester

(2S)-3-(4-tert-butoxycarbonylmethoxy-phenyl)-2-methoxy-propionic acid ethyl ester

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