ethyl 3-benzamido-5-(4-nitrophenylsulfonyl)-5,6-dihydropyrrolo[3,4-cpyrazole-1(4H)-carboxylate]

Base Information

Chemical Name:ethyl 3-benzamido-5-(4-nitrophenylsulfonyl)-5,6-dihydropyrrolo[3,4-cpyrazole-1(4H)-carboxylate]
CAS No.:1414848-69-3
Molecular Formula:C₂₁H₁₉N₅O₇S
Molecular Weight:485.477
Hs Code.:

Synonyms:ethyl 3-benzamido-5-(4-nitrophenylsulfonyl)-5,6-dihydropyrrolo[3,4-cpyrazole-1(4H)-carboxylate]

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Chemical Property of ethyl 3-benzamido-5-(4-nitrophenylsulfonyl)-5,6-dihydropyrrolo[3,4-cpyrazole-1(4H)-carboxylate]

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Technology Process of ethyl 3-benzamido-5-(4-nitrophenylsulfonyl)-5,6-dihydropyrrolo[3,4-cpyrazole-1(4H)-carboxylate]

There total 4 articles about ethyl 3-benzamido-5-(4-nitrophenylsulfonyl)-5,6-dihydropyrrolo[3,4-cpyrazole-1(4H)-carboxylate] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: ethyl 3-benzamido-5,6-dihydropyrrolo[3,4-c]pyrazole-1(4H)-carboxylate dihydrochloride

: 98-74-8
4-Nitrobenzenesulfonyl chloride

: 1414848-69-3
ethyl 3-benzamido-5-(4-nitrophenylsulfonyl)-5,6-dihydropyrrolo[3,4-cpyrazole-1(4H)-carboxylate]

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/j.bmcl.2012.08.117

Reference yield:

: 398495-65-3
3-amino-4,6-dihydro-pyrrolo[3,4-c]pyrazole-1,5-dicarboxylic acid 5-tert-butyl ester 1-ethyl ester

: 1414848-69-3
ethyl 3-benzamido-5-(4-nitrophenylsulfonyl)-5,6-dihydropyrrolo[3,4-cpyrazole-1(4H)-carboxylate]

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 13 h / 0 - 20 °C

2: hydrogenchloride / dichloromethane / 0.5 h / 0 - 5 °C

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2012.08.117

Reference yield:

: 5-tert-butyl 1-ethyl-3-benzamidopyrrolo[3,4-c]pyrazole-1,5(4H,6H)-dicarboxylate

: 1414848-69-3
ethyl 3-benzamido-5-(4-nitrophenylsulfonyl)-5,6-dihydropyrrolo[3,4-cpyrazole-1(4H)-carboxylate]

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / dichloromethane / 0.5 h / 0 - 5 °C

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2012.08.117