N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]methanesulfonamide tosylate salt

Base Information

• Chemical Name: N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]methanesulfonamide tosylate salt
• CAS No.: 1361970-34-4
• Molecular Formula: C₇H₈O₃S*C₂₄H₂₈N₆O₅S
• Molecular Weight: 684.794
• Mol file: 1361970-34-4.mol

Synonyms:N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]methanesulfonamide tosylate salt

Chemical Property of N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]methanesulfonamide tosylate salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]methanesulfonamide tosylate salt

There total 17 articles about N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]methanesulfonamide tosylate salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-bromo-2-chloro-3-nitropyridine (67443-38-3) → N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]methanesulfonamide tosylate salt (1361970-34-4)

Guidance literature:

Multi-step reaction with 7 steps

1.1: methanol / 2.75 h / 0 - 10 °C / Industry scale; Inert atmosphere

2.1: hydrogenchloride; iron / ethanol; water / 23 h / 10 - 25 °C / Industry scale; Inert atmosphere

3.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 2 h / 80 °C / Inert atmosphere

4.1: pyridine / 18 h / 20 °C

5.1: potassium phosphate; potassium hydrogenfluoride / tricyclohexylphosphine; palladium diacetate / isopropyl alcohol; water / 2 h / 75 - 80 °C / Inert atmosphere

6.1: sodium hydroxide; water / 3.08 h / 17 - 23 °C

6.2: 30 °C / pH 6.6

7.1: tetrahydrofuran / 20 °C

With pyridine; hydrogenchloride; potassium phosphate; potassium hydrogenfluoride; water; potassium acetate; iron; sodium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium diacetate; tricyclohexylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; isopropyl alcohol;

Reference yield:

N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]methanesulfonamide (1254036-66-2) + toluene-4-sulfonic acid (104-15-4) → N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]methanesulfonamide tosylate salt (1361970-34-4)

Guidance literature:

In tetrahydrofuran; at 20 ℃;

Reference yield:

5-bromo-2-methoxy-3-nitropyridine (152684-30-5) → N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]methanesulfonamide tosylate salt (1361970-34-4)

Guidance literature:

Multi-step reaction with 6 steps

1.1: hydrogenchloride; iron / ethanol; water / 23 h / 10 - 25 °C / Industry scale; Inert atmosphere

2.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 2 h / 80 °C / Inert atmosphere

3.1: pyridine / 18 h / 20 °C

4.1: potassium phosphate; potassium hydrogenfluoride / tricyclohexylphosphine; palladium diacetate / isopropyl alcohol; water / 2 h / 75 - 80 °C / Inert atmosphere

5.1: sodium hydroxide; water / 3.08 h / 17 - 23 °C

5.2: 30 °C / pH 6.6

6.1: tetrahydrofuran / 20 °C

With pyridine; hydrogenchloride; potassium phosphate; potassium hydrogenfluoride; water; potassium acetate; iron; sodium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium diacetate; tricyclohexylphosphine; In tetrahydrofuran; 1,4-dioxane; ethanol; water; isopropyl alcohol;

upstream raw materials:

N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]methanesulfonamide

toluene-4-sulfonic acid

2-(methyloxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinamine

5-bromo-2-methoxy-3-nitropyridine