2-(4-carboxyphenyl)-5-(5-chlorobenzoxazol-2-yl)-1-(tetrahydropyran-4-yl)benzimidazole

Base Information

Chemical Name:2-(4-carboxyphenyl)-5-(5-chlorobenzoxazol-2-yl)-1-(tetrahydropyran-4-yl)benzimidazole
CAS No.:1256967-65-3
Molecular Formula:C₂₆H₂₀ClN₃O₄
Molecular Weight:473.915
Hs Code.:

Synonyms:2-(4-carboxyphenyl)-5-(5-chlorobenzoxazol-2-yl)-1-(tetrahydropyran-4-yl)benzimidazole

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Chemical Property of 2-(4-carboxyphenyl)-5-(5-chlorobenzoxazol-2-yl)-1-(tetrahydropyran-4-yl)benzimidazole

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Technology Process of 2-(4-carboxyphenyl)-5-(5-chlorobenzoxazol-2-yl)-1-(tetrahydropyran-4-yl)benzimidazole

There total 8 articles about 2-(4-carboxyphenyl)-5-(5-chlorobenzoxazol-2-yl)-1-(tetrahydropyran-4-yl)benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1256967-64-2
5-(5-chlorobenzoxazol-2-yl)-2-(4-methoxycarbonylphenyl)-1-(tetrahydropyran-4-yl)benzimidazole

: 1256967-65-3
2-(4-carboxyphenyl)-5-(5-chlorobenzoxazol-2-yl)-1-(tetrahydropyran-4-yl)benzimidazole

Guidance literature:: 5-(5-chlorobenzoxazol-2-yl)-2-(4-methoxycarbonylphenyl)-1-(tetrahydropyran-4-yl)benzimidazole; With water; sodium hydroxide; In methanol; chloroform; at 20 ℃; for 3h;

With acetic acid; In water; at 20 ℃;

Reference yield:

: 95-85-2
2-hydroxy-5-chloro-aniline

: 1256967-65-3
2-(4-carboxyphenyl)-5-(5-chlorobenzoxazol-2-yl)-1-(tetrahydropyran-4-yl)benzimidazole

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / chloroform / 2 h / 20 °C

2.1: methanesulfonic acid / 1,4-dioxane / 18 h / Reflux

3.1: acetonitrile / 3 h / Reflux

4.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 20 °C

5.1: Oxone / N,N-dimethyl-formamide / 2 h / 20 °C

6.1: water; sodium hydroxide / methanol; chloroform / 3 h / 20 °C

6.2: 20 °C

With Oxone; methanesulfonic acid; water; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; chloroform; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 453-71-4
3-nitro-4-fluorobenzoic acid

: 1256967-65-3
2-(4-carboxyphenyl)-5-(5-chlorobenzoxazol-2-yl)-1-(tetrahydropyran-4-yl)benzimidazole

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / chloroform / 2 h / 20 °C

2.1: methanesulfonic acid / 1,4-dioxane / 18 h / Reflux

3.1: acetonitrile / 3 h / Reflux

4.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 20 °C

5.1: Oxone / N,N-dimethyl-formamide / 2 h / 20 °C

6.1: water; sodium hydroxide / methanol; chloroform / 3 h / 20 °C

6.2: 20 °C

With Oxone; methanesulfonic acid; water; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; chloroform; N,N-dimethyl-formamide; acetonitrile;