5-(5-chlorobenzoxazol-2-yl)-2-(4-n-propylaminocarbonylphenyl)-1-(tetrahydropyran-4-yl)benzimidazole

Base Information

Chemical Name:5-(5-chlorobenzoxazol-2-yl)-2-(4-n-propylaminocarbonylphenyl)-1-(tetrahydropyran-4-yl)benzimidazole
CAS No.:1256967-86-8
Molecular Formula:C₂₉H₂₇ClN₄O₃
Molecular Weight:515.011
Hs Code.:

Synonyms:5-(5-chlorobenzoxazol-2-yl)-2-(4-n-propylaminocarbonylphenyl)-1-(tetrahydropyran-4-yl)benzimidazole

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Chemical Property of 5-(5-chlorobenzoxazol-2-yl)-2-(4-n-propylaminocarbonylphenyl)-1-(tetrahydropyran-4-yl)benzimidazole

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Technology Process of 5-(5-chlorobenzoxazol-2-yl)-2-(4-n-propylaminocarbonylphenyl)-1-(tetrahydropyran-4-yl)benzimidazole

There total 10 articles about 5-(5-chlorobenzoxazol-2-yl)-2-(4-n-propylaminocarbonylphenyl)-1-(tetrahydropyran-4-yl)benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 107-10-8,42939-71-9
propylamine

: C₂₆H₁₉Cl₂N₃O₃

: 1256967-86-8
5-(5-chlorobenzoxazol-2-yl)-2-(4-n-propylaminocarbonylphenyl)-1-(tetrahydropyran-4-yl)benzimidazole

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

: 95-85-2
2-hydroxy-5-chloro-aniline

: 1256967-86-8
5-(5-chlorobenzoxazol-2-yl)-2-(4-n-propylaminocarbonylphenyl)-1-(tetrahydropyran-4-yl)benzimidazole

Guidance literature:: Multi-step reaction with 8 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / chloroform / 2 h / 20 °C

2.1: methanesulfonic acid / 1,4-dioxane / 18 h / Reflux

3.1: acetonitrile / 3 h / Reflux

4.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 20 °C

5.1: Oxone / N,N-dimethyl-formamide / 2 h / 20 °C

6.1: water; sodium hydroxide / methanol; chloroform / 3 h / 20 °C

6.2: 20 °C

7.1: thionyl chloride / 2 h / Reflux

8.1: tetrahydrofuran / 2 h / 20 °C

With Oxone; thionyl chloride; methanesulfonic acid; water; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; chloroform; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 453-71-4
3-nitro-4-fluorobenzoic acid

: 1256967-86-8
5-(5-chlorobenzoxazol-2-yl)-2-(4-n-propylaminocarbonylphenyl)-1-(tetrahydropyran-4-yl)benzimidazole

Guidance literature:: Multi-step reaction with 8 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / chloroform / 2 h / 20 °C

2.1: methanesulfonic acid / 1,4-dioxane / 18 h / Reflux

3.1: acetonitrile / 3 h / Reflux

4.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 20 °C

5.1: Oxone / N,N-dimethyl-formamide / 2 h / 20 °C

6.1: water; sodium hydroxide / methanol; chloroform / 3 h / 20 °C

6.2: 20 °C

7.1: thionyl chloride / 2 h / Reflux

8.1: tetrahydrofuran / 2 h / 20 °C

With Oxone; thionyl chloride; methanesulfonic acid; water; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; chloroform; N,N-dimethyl-formamide; acetonitrile;