(2-{[6-(trans-4-tert-butyl-cyclohexyloxy)-naphthalen-2-ylmethyl]-amino}-ethyl)-phosphonic acid diethyl ester

Base Information

Chemical Name:(2-{[6-(trans-4-tert-butyl-cyclohexyloxy)-naphthalen-2-ylmethyl]-amino}-ethyl)-phosphonic acid diethyl ester
CAS No.:1266116-28-2
Molecular Formula:C₂₇H₄₂NO₄P
Molecular Weight:475.609
Hs Code.:

Synonyms:(2-{[6-(trans-4-tert-butyl-cyclohexyloxy)-naphthalen-2-ylmethyl]-amino}-ethyl)-phosphonic acid diethyl ester

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Chemical Property of (2-{[6-(trans-4-tert-butyl-cyclohexyloxy)-naphthalen-2-ylmethyl]-amino}-ethyl)-phosphonic acid diethyl ester

Chemical Property:

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Technology Process of (2-{[6-(trans-4-tert-butyl-cyclohexyloxy)-naphthalen-2-ylmethyl]-amino}-ethyl)-phosphonic acid diethyl ester

There total 10 articles about (2-{[6-(trans-4-tert-butyl-cyclohexyloxy)-naphthalen-2-ylmethyl]-amino}-ethyl)-phosphonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₇H₄₀NO₄P

: 1266116-28-2
(2-{[6-(trans-4-tert-butyl-cyclohexyloxy)-naphthalen-2-ylmethyl]-amino}-ethyl)-phosphonic acid diethyl ester

Guidance literature:: C₂₇H₄₀NO₄P; With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃;

With water; In 1,2-dichloro-ethane; at 20 ℃; for 0.5h;

Reference yield:

: 937-05-3
cis-4-tert-butyl-1-cyclohexanol

: 1266116-28-2
(2-{[6-(trans-4-tert-butyl-cyclohexyloxy)-naphthalen-2-ylmethyl]-amino}-ethyl)-phosphonic acid diethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C

2.1: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / 26 h / 0 - 30 °C

3.1: n-butyllithium / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

3.2: 1 h / -78 °C

3.3: pH 6

4.1: 1,2-dichloro-ethane / 1 h / 20 °C

5.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C

5.2: 0.5 h / 20 °C

With n-butyllithium; di-isopropyl azodicarboxylate; sodium tris(acetoxy)borohydride; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; toluene;

Reference yield:

: 15231-91-1
6-bromo-naphthalen-2-ol

: 1266116-28-2
(2-{[6-(trans-4-tert-butyl-cyclohexyloxy)-naphthalen-2-ylmethyl]-amino}-ethyl)-phosphonic acid diethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / butanone; tert-butyl alcohol / 0.17 h / 110 °C

1.2: 15 h / 110 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

2.2: 1 h / -78 °C

2.3: pH 6

3.1: 1,2-dichloro-ethane / 1 h / 20 °C

4.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C

4.2: 0.5 h / 20 °C

With n-butyllithium; sodium tris(acetoxy)borohydride; caesium carbonate; In tetrahydrofuran; 1,2-dichloro-ethane; butanone; tert-butyl alcohol;