(2-{[6-(trans-4-tert-butyl-cyclohexyloxy)-naphthalen-2-ylmethyl]-amino}-ethyl)phosphonic acid

Base Information

Chemical Name:(2-{[6-(trans-4-tert-butyl-cyclohexyloxy)-naphthalen-2-ylmethyl]-amino}-ethyl)phosphonic acid
CAS No.:1266116-32-8
Molecular Formula:C₂₃H₃₄NO₄P
Molecular Weight:419.501
Hs Code.:

Synonyms:(2-{[6-(trans-4-tert-butyl-cyclohexyloxy)-naphthalen-2-ylmethyl]-amino}-ethyl)phosphonic acid

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Chemical Property of (2-{[6-(trans-4-tert-butyl-cyclohexyloxy)-naphthalen-2-ylmethyl]-amino}-ethyl)phosphonic acid

Chemical Property:

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Technology Process of (2-{[6-(trans-4-tert-butyl-cyclohexyloxy)-naphthalen-2-ylmethyl]-amino}-ethyl)phosphonic acid

There total 11 articles about (2-{[6-(trans-4-tert-butyl-cyclohexyloxy)-naphthalen-2-ylmethyl]-amino}-ethyl)phosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1266116-28-2
(2-{[6-(trans-4-tert-butyl-cyclohexyloxy)-naphthalen-2-ylmethyl]-amino}-ethyl)-phosphonic acid diethyl ester

: 1266116-32-8
(2-{[6-(trans-4-tert-butyl-cyclohexyloxy)-naphthalen-2-ylmethyl]-amino}-ethyl)phosphonic acid

Guidance literature:: With trimethylsilyl bromide; In acetonitrile; at 50 ℃;

Reference yield:

: 937-05-3
cis-4-tert-butyl-1-cyclohexanol

: 1266116-32-8
(2-{[6-(trans-4-tert-butyl-cyclohexyloxy)-naphthalen-2-ylmethyl]-amino}-ethyl)phosphonic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C

2.1: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / 26 h / 0 - 30 °C

3.1: n-butyllithium / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

3.2: 1 h / -78 °C

3.3: pH 6

4.1: 1,2-dichloro-ethane / 1 h / 20 °C

5.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C

5.2: 0.5 h / 20 °C

6.1: trimethylsilyl bromide / acetonitrile / 50 °C

With n-butyllithium; trimethylsilyl bromide; di-isopropyl azodicarboxylate; sodium tris(acetoxy)borohydride; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; toluene; acetonitrile;

Reference yield:

: 15231-91-1
6-bromo-naphthalen-2-ol

: 1266116-32-8
(2-{[6-(trans-4-tert-butyl-cyclohexyloxy)-naphthalen-2-ylmethyl]-amino}-ethyl)phosphonic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate / butanone; tert-butyl alcohol / 0.17 h / 110 °C

1.2: 15 h / 110 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

2.2: 1 h / -78 °C

2.3: pH 6

3.1: 1,2-dichloro-ethane / 1 h / 20 °C

4.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C

4.2: 0.5 h / 20 °C

5.1: trimethylsilyl bromide / acetonitrile / 50 °C

With n-butyllithium; trimethylsilyl bromide; sodium tris(acetoxy)borohydride; caesium carbonate; In tetrahydrofuran; 1,2-dichloro-ethane; acetonitrile; butanone; tert-butyl alcohol;