1-[4-((3-chloro-5-(trifluoromethyl)-2-pyridinyl)oxy)-2-hydroxyphenyl]ethanone

Base Information

• Chemical Name: 1-[4-((3-chloro-5-(trifluoromethyl)-2-pyridinyl)oxy)-2-hydroxyphenyl]ethanone
• CAS No.: 451456-58-9
• Molecular Formula: C₁₄H₉ClF₃NO₃
• Molecular Weight: 331.679

Synonyms:1-[4-((3-chloro-5-(trifluoromethyl)-2-pyridinyl)oxy)-2-hydroxyphenyl]ethanone

Chemical Property of 1-[4-((3-chloro-5-(trifluoromethyl)-2-pyridinyl)oxy)-2-hydroxyphenyl]ethanone

Chemical Property:

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Technology Process of 1-[4-((3-chloro-5-(trifluoromethyl)-2-pyridinyl)oxy)-2-hydroxyphenyl]ethanone

There total 1 articles about 1-[4-((3-chloro-5-(trifluoromethyl)-2-pyridinyl)oxy)-2-hydroxyphenyl]ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

2',4'-dihydroxy-4-acetophenone (89-84-9) + 2-fluoro-3-chloro-5-(trifluoromethyl)pyridine (72537-17-8) → 1-[4-((3-chloro-5-(trifluoromethyl)-2-pyridinyl)oxy)-2-hydroxyphenyl]ethanone (451456-58-9)

Guidance literature:

With potassium carbonate; In acetonitrile; for 2h; Heating;

DOI:10.1021/jf0116395

Reference yield: 68.0%

3-Chloro-2-methylpropene (563-47-3) + 1-[4-((3-chloro-5-(trifluoromethyl)-2-pyridinyl)oxy)-2-hydroxyphenyl]ethanone (451456-58-9) → 1-[(4-(3-chloro-5-(trifluoromethyl)-2-pyridinyl)oxy)-2-((2-methyl-propenyl)oxy)phenyl]ethanone (451456-63-6)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 75 ℃; for 1h;

DOI:10.1021/jf0116395

Reference yield: 58.0%

epichlorohydrin (106-89-8,24969-06-0,13403-37-7) + 1-[4-((3-chloro-5-(trifluoromethyl)-2-pyridinyl)oxy)-2-hydroxyphenyl]ethanone (451456-58-9) → 1-[4-((3-chloro-5-(trifluoromethyl)-2-pyridinyl)oxy)-2-(2-oxiranylmethoxy)phenyl]ethanone (451456-59-0)

Guidance literature:

With potassium hydroxide; In ethanol; for 1.5h; Heating;

DOI:10.1021/jf0116395

upstream raw materials:

2',4'-dihydroxy-4-acetophenone

2-fluoro-3-chloro-5-(trifluoromethyl)pyridine

Downstream raw materials:

1-[4-((3-chloro-5-(trifluoromethyl)-2-pyridinyl)oxy)-2-(2-oxiranylmethoxy)phenyl]ethanone

1-[(4-(3-chloro-5-(trifluoromethyl)-2-pyridinyl)oxy)-2-((2-methyl-propenyl)oxy)phenyl]ethanone

4-[(3-chloro-5-(trifluoromethyl)-2-pyridinyl)oxy]-2-[(2-methyl-2-oxiranyl)methoxy]phenyl acetate

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