tert-butyl [(2Z,3R,6S)-6-(2,3-difluorophenyl)-2-({2-hydroxy-2-[1-(trifluoromethyl)cyclopropyl]ethyl}imino)azepan-3-yl]carbamate

Base Information

Chemical Name:tert-butyl [(2Z,3R,6S)-6-(2,3-difluorophenyl)-2-({2-hydroxy-2-[1-(trifluoromethyl)cyclopropyl]ethyl}imino)azepan-3-yl]carbamate
CAS No.:1092935-86-8
Molecular Formula:C₂₃H₃₀F₅N₃O₃
Molecular Weight:491.502
Hs Code.:

Synonyms:tert-butyl [(2Z,3R,6S)-6-(2,3-difluorophenyl)-2-({2-hydroxy-2-[1-(trifluoromethyl)cyclopropyl]ethyl}imino)azepan-3-yl]carbamate

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Chemical Property of tert-butyl [(2Z,3R,6S)-6-(2,3-difluorophenyl)-2-({2-hydroxy-2-[1-(trifluoromethyl)cyclopropyl]ethyl}imino)azepan-3-yl]carbamate

Chemical Property:

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Technology Process of tert-butyl [(2Z,3R,6S)-6-(2,3-difluorophenyl)-2-({2-hydroxy-2-[1-(trifluoromethyl)cyclopropyl]ethyl}imino)azepan-3-yl]carbamate

There total 11 articles about tert-butyl [(2Z,3R,6S)-6-(2,3-difluorophenyl)-2-({2-hydroxy-2-[1-(trifluoromethyl)cyclopropyl]ethyl}imino)azepan-3-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 880144-61-6
2-amino-1-[1-(trifluoromethyl)cyclopropyl]ethanol

: 880144-46-7
tert-butyl (3R,6S)-6-(2,3-difluorophenyl)-2-thioxoazepan-3-ylcarbamate

: 1092935-86-8
tert-butyl [(2Z,3R,6S)-6-(2,3-difluorophenyl)-2-({2-hydroxy-2-[1-(trifluoromethyl)cyclopropyl]ethyl}imino)azepan-3-yl]carbamate

Guidance literature:: With mercury dichloride; In ethanol; at 60 ℃; for 0.166667h;

Reference yield:

: 880144-61-6
2-amino-1-[1-(trifluoromethyl)cyclopropyl]ethanol

: 880144-46-7
tert-butyl (3R,6S)-6-(2,3-difluorophenyl)-2-thioxoazepan-3-ylcarbamate

: 1092935-86-8
C₂₃H₃₀F₅N₃O₃

Guidance literature:: With mercury dichloride; In ethanol; at 55 ℃;
DOI:10.1016/j.bmcl.2010.12.054

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1092935-86-8
tert-butyl [(2Z,3R,6S)-6-(2,3-difluorophenyl)-2-({2-hydroxy-2-[1-(trifluoromethyl)cyclopropyl]ethyl}imino)azepan-3-yl]carbamate

Guidance literature:: Multi-step reaction with 8 steps

1.1: methanol; hexane; dichloromethane / 1 h / 0 °C

1.2: 24 h / 20 °C

2.1: diisobutylaluminium hydride / diethyl ether; toluene / 0.58 h / -78 - -65 °C

2.2: 0.5 h / -65 - 20 °C

3.1: N,N,N',N'-tetramethylguanidine / toluene / 0.5 h / 0 °C

3.2: 1.5 h / 0 - 20 °C

4.1: 1,4-dioxane; water / 0.25 h / Inert atmosphere

4.2: 6 h / 20 - 35 °C

5.1: hydrogen / palladium 10% on activated carbon / ethanol / 36 h / 2844.39 Torr

6.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 1 h

7.1: Lawessons reagent / toluene / 1 h / 90 °C

8.1: mercury dichloride / ethanol / 0.17 h / 60 °C

With Lawessons reagent; 1-hydroxy-7-aza-benzotriazole; hydrogen; diisobutylaluminium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; mercury dichloride; N,N,N',N'-tetramethylguanidine; palladium 10% on activated carbon; In 1,4-dioxane; methanol; diethyl ether; ethanol; hexane; dichloromethane; water; toluene;