tert-butyl {(6S,9R)-6-(2,3-difluorophenyl)-3-[1-(trifluoromethyl)cyclopropyl]-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-9-yl}carbamate

Base Information

Chemical Name:tert-butyl {(6S,9R)-6-(2,3-difluorophenyl)-3-[1-(trifluoromethyl)cyclopropyl]-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-9-yl}carbamate
CAS No.:880144-47-8
Molecular Formula:C₂₃H₂₆F₅N₃O₂
Molecular Weight:471.47
Hs Code.:

Synonyms:tert-butyl {(6S,9R)-6-(2,3-difluorophenyl)-3-[1-(trifluoromethyl)cyclopropyl]-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-9-yl}carbamate

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Chemical Property of tert-butyl {(6S,9R)-6-(2,3-difluorophenyl)-3-[1-(trifluoromethyl)cyclopropyl]-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-9-yl}carbamate

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Technology Process of tert-butyl {(6S,9R)-6-(2,3-difluorophenyl)-3-[1-(trifluoromethyl)cyclopropyl]-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-9-yl}carbamate

There total 11 articles about tert-butyl {(6S,9R)-6-(2,3-difluorophenyl)-3-[1-(trifluoromethyl)cyclopropyl]-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-9-yl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1092935-86-8
tert-butyl [(2Z,3R,6S)-6-(2,3-difluorophenyl)-2-({2-hydroxy-2-[1-(trifluoromethyl)cyclopropyl]ethyl}imino)azepan-3-yl]carbamate

: 880144-47-8
tert-butyl {(6S,9R)-6-(2,3-difluorophenyl)-3-[1-(trifluoromethyl)cyclopropyl]-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-9-yl}carbamate

Guidance literature:: With dipyridinium dichromate; In acetonitrile; at 20 ℃; for 70h;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 880144-47-8
tert-butyl {(6S,9R)-6-(2,3-difluorophenyl)-3-[1-(trifluoromethyl)cyclopropyl]-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-9-yl}carbamate

Guidance literature:: Multi-step reaction with 9 steps

1.1: methanol; hexane; dichloromethane / 1 h / 0 °C

1.2: 24 h / 20 °C

2.1: diisobutylaluminium hydride / diethyl ether; toluene / 0.58 h / -78 - -65 °C

2.2: 0.5 h / -65 - 20 °C

3.1: N,N,N',N'-tetramethylguanidine / toluene / 0.5 h / 0 °C

3.2: 1.5 h / 0 - 20 °C

4.1: 1,4-dioxane; water / 0.25 h / Inert atmosphere

4.2: 6 h / 20 - 35 °C

5.1: hydrogen / palladium 10% on activated carbon / ethanol / 36 h / 2844.39 Torr

6.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 1 h

7.1: Lawessons reagent / toluene / 1 h / 90 °C

8.1: mercury dichloride / ethanol / 0.17 h / 60 °C

9.1: dipyridinium dichromate / acetonitrile / 70 h / 20 °C

With Lawessons reagent; dipyridinium dichromate; 1-hydroxy-7-aza-benzotriazole; hydrogen; diisobutylaluminium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; mercury dichloride; N,N,N',N'-tetramethylguanidine; palladium 10% on activated carbon; In 1,4-dioxane; methanol; diethyl ether; ethanol; hexane; dichloromethane; water; toluene; acetonitrile;

Reference yield:

: 784156-33-8
benzyl (2R,5E)-2-[bis(tert-butoxycarbonyl)amino]-6-nitrohex-5-enoate

: 880144-47-8
tert-butyl {(6S,9R)-6-(2,3-difluorophenyl)-3-[1-(trifluoromethyl)cyclopropyl]-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-9-yl}carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1,4-dioxane; water / 0.25 h / Inert atmosphere

1.2: 6 h / 20 - 35 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 36 h / 2844.39 Torr

3.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 1 h

4.1: Lawessons reagent / toluene / 1 h / 90 °C

5.1: mercury dichloride / ethanol / 0.17 h / 60 °C

6.1: dipyridinium dichromate / acetonitrile / 70 h / 20 °C

With Lawessons reagent; dipyridinium dichromate; 1-hydroxy-7-aza-benzotriazole; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; mercury dichloride; palladium 10% on activated carbon; In 1,4-dioxane; ethanol; dichloromethane; water; toluene; acetonitrile;