3-(4-chlorophenyl)-7a-methyl-7,7a-dihydrofuran[3,2-d][1,2]oxathin-5,5-dioxide-2(4H)-one

Base Information

Chemical Name:3-(4-chlorophenyl)-7a-methyl-7,7a-dihydrofuran[3,2-d][1,2]oxathin-5,5-dioxide-2(4H)-one
CAS No.:1589532-63-7
Molecular Formula:C₁₃H₁₁ClO₅S
Molecular Weight:314.746
Hs Code.:

Synonyms:3-(4-chlorophenyl)-7a-methyl-7,7a-dihydrofuran[3,2-d][1,2]oxathin-5,5-dioxide-2(4H)-one

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Chemical Property of 3-(4-chlorophenyl)-7a-methyl-7,7a-dihydrofuran[3,2-d][1,2]oxathin-5,5-dioxide-2(4H)-one

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Technology Process of 3-(4-chlorophenyl)-7a-methyl-7,7a-dihydrofuran[3,2-d][1,2]oxathin-5,5-dioxide-2(4H)-one

There total 6 articles about 3-(4-chlorophenyl)-7a-methyl-7,7a-dihydrofuran[3,2-d][1,2]oxathin-5,5-dioxide-2(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1589533-39-0
C₁₄H₁₅ClO₆S

: 1589532-63-7
3-(4-chlorophenyl)-7a-methyl-7,7a-dihydrofuran[3,2-d][1,2]oxathin-5,5-dioxide-2(4H)-one

Guidance literature:: With sodium hydroxide; In N,N-dimethyl-formamide; at 85 ℃;
DOI:10.1016/j.bmcl.2014.03.012

Reference yield:

: 1589533-28-7
3-(4-difluorophenyl)-5-(hydroxymethyl)-4-methoxyfuran-2(5H)-one

: 1589532-63-7
3-(4-chlorophenyl)-7a-methyl-7,7a-dihydrofuran[3,2-d][1,2]oxathin-5,5-dioxide-2(4H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0 °C

2: sodium hydroxide / N,N-dimethyl-formamide / 85 °C

With triethylamine; sodium hydroxide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2014.03.012

Reference yield:

: 1878-66-6
4-chlorophenylacetic Acid

: 1589532-63-7
3-(4-chlorophenyl)-7a-methyl-7,7a-dihydrofuran[3,2-d][1,2]oxathin-5,5-dioxide-2(4H)-one

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / toluene; tetrahydrofuran / Reflux

2: potassium tert-butylate / toluene; N,N-dimethyl-formamide / 0 - 20 °C

3: potassium carbonate / acetone

4: sodium methylate / methanol / Reflux

5: triethylamine / dichloromethane / 0 °C

6: sodium hydroxide / N,N-dimethyl-formamide / 85 °C

With potassium tert-butylate; sodium methylate; potassium carbonate; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetone; toluene; 4: |Aldol Condensation;
DOI:10.1016/j.bmcl.2014.03.012