ethyl 6-(bromomethyl)-1-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydro pyrimidine-5-carboxylate

Base Information

• Chemical Name: ethyl 6-(bromomethyl)-1-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydro pyrimidine-5-carboxylate
• CAS No.: 14758-01-1
• Molecular Formula: C₁₅H₁₇BrN₂O₃
• Molecular Weight: 353.216
• Mol file: 14758-01-1.mol

Synonyms:ethyl 6-(bromomethyl)-1-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydro pyrimidine-5-carboxylate

Chemical Property of ethyl 6-(bromomethyl)-1-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydro pyrimidine-5-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 6-(bromomethyl)-1-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydro pyrimidine-5-carboxylate

There total 4 articles about ethyl 6-(bromomethyl)-1-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydro pyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

ethyl 1,6-dimethyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate (123044-27-9,50628-42-7) → ethyl 6-(bromomethyl)-1-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydro pyrimidine-5-carboxylate (14758-01-1)

Guidance literature:

With bromine; In chloroform; at 4 - 20 ℃; for 18h;

DOI:10.1016/j.ejmech.2018.07.004

Reference yield:

benzaldehyde (100-52-7) → ethyl 6-(bromomethyl)-1-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydro pyrimidine-5-carboxylate (14758-01-1)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / ethanol / 3 h / Reflux

2: bromine / chloroform / 18 h / 4 - 20 °C

With hydrogenchloride; bromine; In ethanol; chloroform;

DOI:10.1016/j.ejmech.2018.07.004

Reference yield:

ethyl acetoacetate (141-97-9) → ethyl 6-(bromomethyl)-1-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydro pyrimidine-5-carboxylate (14758-01-1)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / ethanol / 3 h / Reflux

2: bromine / chloroform / 18 h / 4 - 20 °C

With hydrogenchloride; bromine; In ethanol; chloroform;

DOI:10.1016/j.ejmech.2018.07.004

upstream raw materials:

ethyl acetoacetate

benzaldehyde

ethyl 1,6-dimethyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate