tert-butyl (1-(4-(2-oxo-7-phenyl-1-(prop-2-yn-1-yl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl)phenyl)cyclobutyl)carbamate

Base Information

Chemical Name:tert-butyl (1-(4-(2-oxo-7-phenyl-1-(prop-2-yn-1-yl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl)phenyl)cyclobutyl)carbamate
CAS No.:1313440-31-1
Molecular Formula:C₃₁H₃₁N₃O₄
Molecular Weight:509.605
Hs Code.:

Synonyms:tert-butyl (1-(4-(2-oxo-7-phenyl-1-(prop-2-yn-1-yl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl)phenyl)cyclobutyl)carbamate

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Chemical Property of tert-butyl (1-(4-(2-oxo-7-phenyl-1-(prop-2-yn-1-yl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl)phenyl)cyclobutyl)carbamate

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Technology Process of tert-butyl (1-(4-(2-oxo-7-phenyl-1-(prop-2-yn-1-yl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl)phenyl)cyclobutyl)carbamate

There total 5 articles about tert-butyl (1-(4-(2-oxo-7-phenyl-1-(prop-2-yn-1-yl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl)phenyl)cyclobutyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1313440-29-7
tert-butyl (1-(4-(2-oxo-7-phenyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl)phenyl)cyclobutyl)carbamate

: 106-96-7
propargyl bromide

: 1313440-31-1
tert-butyl (1-(4-(2-oxo-7-phenyl-1-(prop-2-yn-1-yl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl)phenyl)cyclobutyl)carbamate

Guidance literature:: tert-butyl (1-(4-(2-oxo-7-phenyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl)phenyl)cyclobutyl)carbamate; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 1h; Inert atmosphere;

propargyl bromide; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

Reference yield:

: 1313440-25-3
(E)-tert-butyl (1-(4-(3-(dimethylamino)-2-phenylacryloyl)phenyl)cyclobutyl)carbamate

: 1313440-31-1
tert-butyl (1-(4-(2-oxo-7-phenyl-1-(prop-2-yn-1-yl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl)phenyl)cyclobutyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; methanol / 16 h / 0 - 40 °C

2.1: sodium hydroxide; dihydrogen peroxide / ethanol; water / 16 h / 20 - 50 °C

2.2: 0 °C / pH 4

3.1: sodium hydroxide; bromine / water / 24 h / 0 - 65 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 0 - 20 °C

4.2: 16 h / 115 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C / Inert atmosphere

5.2: 1 h / 0 °C

With dihydrogen peroxide; bromine; sodium hydride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1313440-26-4
tert-butyl (1-(4-(5-cyano-6-hydroxy-3-phenylpyridin-2-yl)phenyl)cyclobutyl)carbamate

: 1313440-31-1
tert-butyl (1-(4-(2-oxo-7-phenyl-1-(prop-2-yn-1-yl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl)phenyl)cyclobutyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide; dihydrogen peroxide / ethanol; water / 16 h / 20 - 50 °C

1.2: 0 °C / pH 4

2.1: sodium hydroxide; bromine / water / 24 h / 0 - 65 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 0 - 20 °C

3.2: 16 h / 115 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C / Inert atmosphere

4.2: 1 h / 0 °C

With dihydrogen peroxide; bromine; sodium hydride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;