tert-butyl (1-(4-(5-cyano-6-hydroxy-3-phenylpyridin-2-yl)phenyl)cyclobutyl)carbamate

Base Information

Chemical Name:tert-butyl (1-(4-(5-cyano-6-hydroxy-3-phenylpyridin-2-yl)phenyl)cyclobutyl)carbamate
CAS No.:1313440-26-4
Molecular Formula:C₂₇H₂₇N₃O₃
Molecular Weight:441.53
Hs Code.:

Synonyms:tert-butyl (1-(4-(5-cyano-6-hydroxy-3-phenylpyridin-2-yl)phenyl)cyclobutyl)carbamate

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Chemical Property of tert-butyl (1-(4-(5-cyano-6-hydroxy-3-phenylpyridin-2-yl)phenyl)cyclobutyl)carbamate

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Technology Process of tert-butyl (1-(4-(5-cyano-6-hydroxy-3-phenylpyridin-2-yl)phenyl)cyclobutyl)carbamate

There total 1 articles about tert-butyl (1-(4-(5-cyano-6-hydroxy-3-phenylpyridin-2-yl)phenyl)cyclobutyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1313440-25-3
(E)-tert-butyl (1-(4-(3-(dimethylamino)-2-phenylacryloyl)phenyl)cyclobutyl)carbamate

: 107-91-5
cyanoacetic acid amide

: 1313440-26-4
tert-butyl (1-(4-(5-cyano-6-hydroxy-3-phenylpyridin-2-yl)phenyl)cyclobutyl)carbamate

Guidance literature:: With sodium hydride; In methanol; N,N-dimethyl-formamide; at 0 - 40 ℃; for 16h;

Reference yield: 72.0%

: 1313440-26-4
tert-butyl (1-(4-(5-cyano-6-hydroxy-3-phenylpyridin-2-yl)phenyl)cyclobutyl)carbamate

: 1313440-27-5
tert-butyl (1-(4-(5-carbamoyl-6-hydroxy-3-phenylpyridin-2-yl)phenyl)cyclobutyl)carbamate

Guidance literature:: tert-butyl (1-(4-(5-cyano-6-hydroxy-3-phenylpyridin-2-yl)phenyl)cyclobutyl)carbamate; With dihydrogen peroxide; sodium hydroxide; In ethanol; water; at 20 - 50 ℃; for 16h;

With acetic acid; In ethanol; water; at 0 ℃; pH=4;

Reference yield:

: 1313440-26-4
tert-butyl (1-(4-(5-cyano-6-hydroxy-3-phenylpyridin-2-yl)phenyl)cyclobutyl)carbamate

: 1313440-33-3
tert-butyl (1-(4-(1-(2-(dimethylamino)ethyl)-2-oxo-7-phenyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl)phenyl)cyclobutyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide; dihydrogen peroxide / ethanol; water / 16 h / 20 - 50 °C

1.2: 0 °C / pH 4

2.1: sodium hydroxide; bromine / water / 24 h / 0 - 65 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 0 - 20 °C

3.2: 16 h / 115 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C / Inert atmosphere

4.2: 5 h / 40 °C

With dihydrogen peroxide; bromine; sodium hydride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;