Technology Process of ((2R,3S,4R,5R,6S)-6-(4-chloro-3-((5-(thiophen-3-yl)thiazol-2-yl)methyl)phenyl)-3,4,5-trihydroxy-tetrahydro-2H-pyran-2-yl)methyl 3,4-dimethoxybenzoate
There total 9 articles about ((2R,3S,4R,5R,6S)-6-(4-chloro-3-((5-(thiophen-3-yl)thiazol-2-yl)methyl)phenyl)-3,4,5-trihydroxy-tetrahydro-2H-pyran-2-yl)methyl 3,4-dimethoxybenzoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
pyridine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
dichloromethane;
at 20 ℃;
for 16h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 15 h / 20 °C / Inert atmosphere
2.1: Lawessons reagent / tetrahydrofuran / Reflux; Inert atmosphere
3.1: trimethylsilyl iodide / acetonitrile / 24 h / 50 °C / Inert atmosphere
3.2: 0 °C / Inert atmosphere
4.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; pyridine / dichloromethane / 16 h / 20 °C
With
Lawessons reagent; 4-methyl-morpholine; pyridine; dmap; trimethylsilyl iodide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydroxide; water / ethanol / Reflux
1.2: 20 °C
2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 15 h / 20 °C / Inert atmosphere
3.1: Lawessons reagent / tetrahydrofuran / Reflux; Inert atmosphere
4.1: trimethylsilyl iodide / acetonitrile / 24 h / 50 °C / Inert atmosphere
4.2: 0 °C / Inert atmosphere
5.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; pyridine / dichloromethane / 16 h / 20 °C
With
Lawessons reagent; 4-methyl-morpholine; pyridine; dmap; trimethylsilyl iodide; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide;
In
tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;