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1225430-39-6

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1225430-39-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1225430-39-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,2,5,4,3 and 0 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1225430-39:
(9*1)+(8*2)+(7*2)+(6*5)+(5*4)+(4*3)+(3*0)+(2*3)+(1*9)=116
116 % 10 = 6
So 1225430-39-6 is a valid CAS Registry Number.

1225430-39-6Downstream Products

1225430-39-6Relevant articles and documents

THIAZOLE DERIVATIVES AS SGLT2 INHIBITORS AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

-

, (2012/01/06)

The present invention relates to a novel compound with thiazole ring having an inhibitory activity against sodium-dependent glucose cotransporter 2 (SGLT2) being present in the intestine and kidney, and a pharmaceutical composition comprising the same as an active ingredient, which is useful for preventing or treating metabolic disorders, particularly diabetes.

Novel C-aryl glucoside SGLT2 inhibitors as potential antidiabetic agents: 1,3,4-Thiadiazolylmethylphenyl glucoside congeners

Lee, Junwon,Lee, Sung-Han,Seo, Hee Jeong,Son, Eun-Jung,Lee, Suk Ho,Jung, Myung Eun,Lee, MinWoo,Han, Ho-Kyun,Kim, Jeongmin,Kang, Jahyo,Lee, Jinhwa

experimental part, p. 2178 - 2194 (2010/06/12)

Novel C-aryl glucoside SGLT2 inhibitors containing 1,3,4-thiadiazole moieties were designed and synthesized. Among the compounds tested, biaryl-type compounds containing pyrazine 59, 2-furan 61, and 3-thiophene 71 showed the best in vitro inhibitory activities to date (IC50 = 3.51-7.03 nM) against SGLT2. A selected compound 61, demonstrated reasonable blood glucose-lowering effects, indicating that the information obtained from the SAR studies in this 1,3,4-thiadiazolylmethylphenyl glucoside series might help to design more active SGLT2 inhibitors that are structurally related.

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