2-[(1S,3S)-3-aminocyclohexyl]propan-2-ol

Base Information

Chemical Name:2-[(1S,3S)-3-aminocyclohexyl]propan-2-ol
CAS No.:1359985-26-4
Molecular Formula:C₉H₁₉NO
Molecular Weight:157.256
Hs Code.:

Synonyms:2-[(1S,3S)-3-aminocyclohexyl]propan-2-ol

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Chemical Property of 2-[(1S,3S)-3-aminocyclohexyl]propan-2-ol

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Technology Process of 2-[(1S,3S)-3-aminocyclohexyl]propan-2-ol

There total 16 articles about 2-[(1S,3S)-3-aminocyclohexyl]propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1359985-25-3
C₁₇H₂₅NO₃

: 1359985-26-4
2-[(1S,3S)-3-aminocyclohexyl]propan-2-ol

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 18h; under 2585.81 Torr;
DOI:10.1055/s-0031-1289884

Reference yield:

: 1359985-32-2
C₁₅H₂₅NO

: 1359985-26-4
2-[(1S,3S)-3-aminocyclohexyl]propan-2-ol

Guidance literature:: C₁₅H₂₅NO; With hydroxylamine hydrochloride; triethylamine; In water; isopropyl alcohol; for 6h; Reflux;

With sodium hydroxide; In water; isopropyl alcohol; at 0 ℃; for 16h;
DOI:10.1055/s-0031-1289884

Reference yield:

: 116724-13-1
trans rac-cyclohexyl 1,3-dicarboxylic acid

: 1359985-26-4
2-[(1S,3S)-3-aminocyclohexyl]propan-2-ol

Guidance literature:: Multi-step reaction with 13 steps

1.1: hydrogenchloride / water / 4 h / 80 °C

2.1: diphenyl phosphoryl azide; triethylamine / toluene / 1 h / 70 °C

3.1: triethylamine / toluene / 5 h / 80 °C

4.1: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 5 h / 20 °C

5.1: borane-THF / tetrahydrofuran / 4 h / -5 °C

6.1: Chiral Pak AD-H 250 column / ethanol; carbon dioxide / 40 °C / Resolution of racemate

7.1: palladium 10% on activated carbon; hydrogen / methanol / 16 h / 2585.81 Torr

8.1: acetic acid / toluene / 2 h / Reflux

9.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 2 h / Molecular sieve

10.1: diethyl ether / 0.5 h / 0 °C

11.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 2 h / Molecular sieve

12.1: diethyl ether / 0.5 h / 0 °C

13.1: hydroxylamine hydrochloride; triethylamine / water; isopropyl alcohol / 6 h / Reflux

13.2: 16 h / 0 °C

With hydrogenchloride; tetrapropylammonium perruthennate; borane-THF; lithium hydroxide monohydrate; diphenyl phosphoryl azide; palladium 10% on activated carbon; hydroxylamine hydrochloride; water; hydrogen; acetic acid; 4-methylmorpholine N-oxide; triethylamine; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; carbon dioxide; water; isopropyl alcohol; toluene; 3.1: Curtius rearrangement / 10.1: Grignard reaction / 12.1: Grignard reaction;
DOI:10.1055/s-0031-1289884