1359985-32-2Relevant academic research and scientific papers
A practical synthesis of [(1 S,3 S)-3-aminocyclohexyl]methanol and 2-[(1 S,3 S)-3-aminocyclohexyl]propan-2-ol, useful intermediates for the preparation of novel m PGES-1 inhibitors
Walker, Daniel P.,Heasley, Steven E.,MacInnes, Allison,Anjeh, Tizah,Lu, Hwang-Fun,Fobian, Yvette M.,Collins, Joe T.,Vazquez, Michael L.,Mao, Michael K.
, p. 2959 - 2962 (2012/01/13)
Microsomal prostaglandin E2 synthase-1 (mPGES-1) is a novel therapeutic target for the treatment of inflammation and pain. During the course of studies aimed at the identification of a suitable mPGES-1 inhibitor for clinical development, a need arose for preparing enantiomerically enriched amino alcohols (S,S)-2 and (S,S)-3. Described herein, a concise synthesis of (S,S)-2 and (S,S)-3 has been developed wherein both amino alcohols are derived from a commercially available, low-cost starting material. Georg Thieme Verlag Stuttgart · New York.
