3-(4'-Fluoro-biphenyl-4-yl)-3-hydroxy-3-m-tolyl-propionic acid ethyl ester

Base Information

• Chemical Name: 3-(4'-Fluoro-biphenyl-4-yl)-3-hydroxy-3-m-tolyl-propionic acid ethyl ester
• CAS No.: 95711-78-7
• Molecular Formula: C₂₄H₂₃FO₃
• Molecular Weight: 378.443
• Mol file: 95711-78-7.mol

Synonyms:3-(4'-Fluoro-biphenyl-4-yl)-3-hydroxy-3-m-tolyl-propionic acid ethyl ester

Chemical Property of 3-(4'-Fluoro-biphenyl-4-yl)-3-hydroxy-3-m-tolyl-propionic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4'-Fluoro-biphenyl-4-yl)-3-hydroxy-3-m-tolyl-propionic acid ethyl ester

There total 2 articles about 3-(4'-Fluoro-biphenyl-4-yl)-3-hydroxy-3-m-tolyl-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

ethyl bromoacetate (105-36-2) + (4'-Fluoro-biphenyl-4-yl)-m-tolyl-methanone (95711-73-2) → 3-(4'-Fluoro-biphenyl-4-yl)-3-hydroxy-3-m-tolyl-propionic acid ethyl ester (95711-78-7)

Guidance literature:

DOI:10.1002/ardp.19853180211

Reference yield:

4-fluoro-biphenyl (324-74-3) → 3-(4'-Fluoro-biphenyl-4-yl)-3-hydroxy-3-m-tolyl-propionic acid ethyl ester (95711-78-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / AlCl₃ / CS₂ / Heating

2: 90 percent

With aluminium trichloride; In carbon disulfide;

DOI:10.1002/ardp.19853180211

Reference yield: 100.0%

3-(4'-Fluoro-biphenyl-4-yl)-3-hydroxy-3-m-tolyl-propionic acid ethyl ester (95711-78-7) → 3-(4'-Fluoro-biphenyl-4-yl)-3-hydroxy-3-m-tolyl-propionic acid (95711-57-2,95711-58-3)

Guidance literature:

With sodium hydroxide; In ethanol;

DOI:10.1002/ardp.19853180211

upstream raw materials:

ethyl bromoacetate

(4'-Fluoro-biphenyl-4-yl)-m-tolyl-methanone

4-fluoro-biphenyl

Downstream raw materials:

3-(4'-Fluoro-biphenyl-4-yl)-3-hydroxy-3-m-tolyl-propionic acid