5-{4-[(2-methyl-4-quinolinyl)methoxy]phenyl}-5-(1-piperazinyl)-2,4,6(1H, 3H, 5H)-pyrimidinetrione

Base Information

Chemical Name:5-{4-[(2-methyl-4-quinolinyl)methoxy]phenyl}-5-(1-piperazinyl)-2,4,6(1H, 3H, 5H)-pyrimidinetrione
CAS No.:556052-20-1
Molecular Formula:C₂₅H₂₅N₅O₄
Molecular Weight:459.505
Hs Code.:

Synonyms:5-{4-[(2-methyl-4-quinolinyl)methoxy]phenyl}-5-(1-piperazinyl)-2,4,6(1H, 3H, 5H)-pyrimidinetrione

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Chemical Property of 5-{4-[(2-methyl-4-quinolinyl)methoxy]phenyl}-5-(1-piperazinyl)-2,4,6(1H, 3H, 5H)-pyrimidinetrione

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Technology Process of 5-{4-[(2-methyl-4-quinolinyl)methoxy]phenyl}-5-(1-piperazinyl)-2,4,6(1H, 3H, 5H)-pyrimidinetrione

There total 6 articles about 5-{4-[(2-methyl-4-quinolinyl)methoxy]phenyl}-5-(1-piperazinyl)-2,4,6(1H, 3H, 5H)-pyrimidinetrione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 556052-18-7
tert-butyl 4-(5-{4-[(2-methyl-4-quinolinyl)methoxy]phenyl}-2,4,6-trioxohexahydro-5-pyrimidinyl)-1-piperazinecarboxylate

: 556052-20-1
5-{4-[(2-methyl-4-quinolinyl)methoxy]phenyl}-5-(1-piperazinyl)-2,4,6(1H, 3H, 5H)-pyrimidinetrione

Guidance literature:: With trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.bmcl.2005.04.039

Reference yield:

: 301162-82-3
[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-acetic acid methyl ester

: 556052-20-1
5-{4-[(2-methyl-4-quinolinyl)methoxy]phenyl}-5-(1-piperazinyl)-2,4,6(1H, 3H, 5H)-pyrimidinetrione

Guidance literature:: Multi-step reaction with 3 steps

1.1: 78 percent / NaH / tetrahydrofuran / Heating

2.1: NaOMe / methanol / Heating

2.2: K₂CO₃; Br₂

3.1: 100 percent / CF₃CO₂H / CH₂Cl₂

With sodium methylate; sodium hydride; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.bmcl.2005.04.039

Reference yield:

: 556052-15-4
2-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-malonic acid dimethyl ester

: 556052-20-1
5-{4-[(2-methyl-4-quinolinyl)methoxy]phenyl}-5-(1-piperazinyl)-2,4,6(1H, 3H, 5H)-pyrimidinetrione

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaOMe / methanol / Heating

1.2: K₂CO₃; Br₂

2.1: 100 percent / CF₃CO₂H / CH₂Cl₂

With sodium methylate; trifluoroacetic acid; In methanol; dichloromethane;
DOI:10.1016/j.bmcl.2005.04.039