tert-butyl 4-(5-{4-[(2-methyl-4-quinolinyl)methoxy]phenyl}-2,4,6-trioxohexahydro-5-pyrimidinyl)-1-piperazinecarboxylate

Base Information

Chemical Name:tert-butyl 4-(5-{4-[(2-methyl-4-quinolinyl)methoxy]phenyl}-2,4,6-trioxohexahydro-5-pyrimidinyl)-1-piperazinecarboxylate
CAS No.:556052-18-7
Molecular Formula:C₃₀H₃₃N₅O₆
Molecular Weight:559.622
Hs Code.:

Synonyms:tert-butyl 4-(5-{4-[(2-methyl-4-quinolinyl)methoxy]phenyl}-2,4,6-trioxohexahydro-5-pyrimidinyl)-1-piperazinecarboxylate

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Chemical Property of tert-butyl 4-(5-{4-[(2-methyl-4-quinolinyl)methoxy]phenyl}-2,4,6-trioxohexahydro-5-pyrimidinyl)-1-piperazinecarboxylate

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Technology Process of tert-butyl 4-(5-{4-[(2-methyl-4-quinolinyl)methoxy]phenyl}-2,4,6-trioxohexahydro-5-pyrimidinyl)-1-piperazinecarboxylate

There total 5 articles about tert-butyl 4-(5-{4-[(2-methyl-4-quinolinyl)methoxy]phenyl}-2,4,6-trioxohexahydro-5-pyrimidinyl)-1-piperazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 301162-82-3
[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-acetic acid methyl ester

: 556052-18-7
tert-butyl 4-(5-{4-[(2-methyl-4-quinolinyl)methoxy]phenyl}-2,4,6-trioxohexahydro-5-pyrimidinyl)-1-piperazinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 78 percent / NaH / tetrahydrofuran / Heating

2.1: NaOMe / methanol / Heating

2.2: K₂CO₃; Br₂

With sodium methylate; sodium hydride; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmcl.2005.04.039

Reference yield:

: 14199-15-6
Methyl 4-hydroxyphenylacetate

: 556052-18-7
tert-butyl 4-(5-{4-[(2-methyl-4-quinolinyl)methoxy]phenyl}-2,4,6-trioxohexahydro-5-pyrimidinyl)-1-piperazinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 72 percent / Cs₂CO₃ / dimethylsulfoxide

2.1: 78 percent / NaH / tetrahydrofuran / Heating

3.1: NaOMe / methanol / Heating

3.2: K₂CO₃; Br₂

With sodium methylate; sodium hydride; caesium carbonate; In tetrahydrofuran; methanol; dimethyl sulfoxide;
DOI:10.1016/j.bmcl.2005.04.039

Reference yield:

: 288399-19-9
4-(chloromethyl)-2-methylquinoline

: 556052-18-7
tert-butyl 4-(5-{4-[(2-methyl-4-quinolinyl)methoxy]phenyl}-2,4,6-trioxohexahydro-5-pyrimidinyl)-1-piperazinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 72 percent / Cs₂CO₃ / dimethylsulfoxide

2.1: 78 percent / NaH / tetrahydrofuran / Heating

3.1: NaOMe / methanol / Heating

3.2: K₂CO₃; Br₂

With sodium methylate; sodium hydride; caesium carbonate; In tetrahydrofuran; methanol; dimethyl sulfoxide;
DOI:10.1016/j.bmcl.2005.04.039