ethyl 4-{[6-(2-methoxyphenyl)pyrimidin-4-yl]amino}phenyl ethylphosphonate

Base Information

Chemical Name:ethyl 4-{[6-(2-methoxyphenyl)pyrimidin-4-yl]amino}phenyl ethylphosphonate
CAS No.:1606168-35-7
Molecular Formula:C₂₁H₂₄N₃O₄P
Molecular Weight:413.413
Hs Code.:

Synonyms:ethyl 4-{[6-(2-methoxyphenyl)pyrimidin-4-yl]amino}phenyl ethylphosphonate

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Chemical Property of ethyl 4-{[6-(2-methoxyphenyl)pyrimidin-4-yl]amino}phenyl ethylphosphonate

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Technology Process of ethyl 4-{[6-(2-methoxyphenyl)pyrimidin-4-yl]amino}phenyl ethylphosphonate

There total 3 articles about ethyl 4-{[6-(2-methoxyphenyl)pyrimidin-4-yl]amino}phenyl ethylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1606168-16-4
4-{[6-(2-methoxyphenyl)pyrimidin-4-yl]amino}phenol

: 5284-10-6
ethyl ethylphosphonochloridate

: 1606168-35-7
ethyl 4-{[6-(2-methoxyphenyl)pyrimidin-4-yl]amino}phenyl ethylphosphonate

Guidance literature:: 4-{[6-(2-methoxyphenyl)pyrimidin-4-yl]amino}phenol; With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 0.5h;

ethyl ethylphosphonochloridate; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/jm401742r

Reference yield:

: 75634-03-6
4-chloro-6-(2-methoxy-phenyl)-pyrimidine

: 1606168-35-7
ethyl 4-{[6-(2-methoxyphenyl)pyrimidin-4-yl]amino}phenyl ethylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / isopropyl alcohol; water / 1 h / Reflux

2.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 20 °C

2.2: 20 °C

With hydrogenchloride; potassium tert-butylate; In tetrahydrofuran; water; isopropyl alcohol;
DOI:10.1021/jm401742r

Reference yield:

: 123-30-8
4-amino-phenol

: 1606168-35-7
ethyl 4-{[6-(2-methoxyphenyl)pyrimidin-4-yl]amino}phenyl ethylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / isopropyl alcohol; water / 1 h / Reflux

2.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 20 °C

2.2: 20 °C

With hydrogenchloride; potassium tert-butylate; In tetrahydrofuran; water; isopropyl alcohol;
DOI:10.1021/jm401742r