4-Chloro-6-(2-methoxy-phenyl)-pyrimidine

Base Information

• Chemical Name: 4-Chloro-6-(2-methoxy-phenyl)-pyrimidine
• CAS No.: 75634-03-6
• Molecular Formula: C11H9ClN2O
• Molecular Weight: 220.658

Synonyms:4-chloro-6-(2-methoxyphenyl)-pyrimidine;4-chloro-6-(2-methoxy-phenyl)pyrimidine;4-chloro-6-(2'-methoxyphenyl)pyrimidine;4-chloro-6-(2-methoxyphenyl)pyrimidine;4-Chloro-6-(2-methoxy-phenyl)-pyrimidine;

Chemical Property of 4-Chloro-6-(2-methoxy-phenyl)-pyrimidine

Chemical Property:

• PSA: 35.01000
• LogP: 2.80560

Purity/Quality:

99% ^*data from raw suppliers

4-Chloro-6-(2-methoxyphenyl)pyrimidine 97% ^*data from reagent suppliers

Safty Information:

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MSDS Files:

Useful:

Technology Process of 4-Chloro-6-(2-methoxy-phenyl)-pyrimidine

There total 1 articles about 4-Chloro-6-(2-methoxy-phenyl)-pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4,6-dichloropyrimidine (1193-21-1) + 2-Methoxyphenylboronic acid (5720-06-9) → 4-chloro-6-(2-methoxy-phenyl)-pyrimidine (75634-03-6)

Guidance literature:

With palladium diacetate; sodium carbonate; triphenylphosphine; In tetrahydrofuran; water; at 60 ℃; for 16h; Inert atmosphere;

DOI:10.1016/j.bmcl.2016.11.052

Reference yield: 92.0%

4-methoxy-3-methoxycarbonyl-phenyl-ammonium chloride (99450-55-2) + 4-chloro-6-(2-methoxy-phenyl)-pyrimidine (75634-03-6) → (4-methoxy-3-methoxycarbonyl-phenyl)-[6-(2-methoxy-phenyl)-pyrimidin-4-yl]-ammonium chloride (1569986-04-4)

Guidance literature:

In tert-butyl alcohol; for 6h; Reflux;

Reference yield: 87.9%

4-chloro-6-(2-methoxy-phenyl)-pyrimidine (75634-03-6) → 6-(2-methoxyphenyl)pyrimidin-4-amine (1142004-97-4)

Guidance literature:

With ammonia; In 1,4-dioxane; at 110 ℃; for 8h; Product distribution / selectivity;

upstream raw materials:

4,6-dichloropyrimidine

2-Methoxyphenylboronic acid

Downstream raw materials:

C-{3-[6-(2-methoxy-phenyl)-pyrimidin-4-ylamino]-phenyl}-N,N-dimethyl-methanesulfonamide

C-{3-[6-(2-methoxy-phenyl)-pyrimidin-4-ylamino]-phenyl}-N-(3-methoxy-propyl)-methanesulfonamide

C-(3-[6-(2-methoxy-phenyl)-pyrimidin-4-ylamino]-phenyl)-N-propyl-methanesulfonamide

C-(3-[6-(2-methoxy-phenyl)-pyrimidin-4-ylamino]-phenyl)-N-methyl-methanesulfonamide

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