methyl O--(S)-2-hydroxy-3-phenylpropanoate

Base Information

• Chemical Name: methyl O--(S)-2-hydroxy-3-phenylpropanoate
• CAS No.: 131066-56-3
• Molecular Formula: C₂₄H₂₉NO₆
• Molecular Weight: 427.497
• Mol file: 131066-56-3.mol

Synonyms:methyl O--(S)-2-hydroxy-3-phenylpropanoate

Chemical Property of methyl O--(S)-2-hydroxy-3-phenylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of methyl O--(S)-2-hydroxy-3-phenylpropanoate

There total 1 articles about methyl O--(S)-2-hydroxy-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

Z-Leu-OH (2018-66-8) + (S)-methyl 2-hydroxy-3-phenylpropanoate (13673-95-5) → methyl O--(S)-2-hydroxy-3-phenylpropanoate (131066-56-3)

Guidance literature:

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; Ambient temperature;

DOI:10.1021/ja00001a043

Reference yield:

methyl O--(S)-2-hydroxy-3-phenylpropanoate (131066-56-3) → (S)-2-Amino-4-methyl-pentanoic acid (S)-1-methoxycarbonyl-2-phenyl-ethyl ester

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; for 5h;

DOI:10.1021/ja00001a043

Reference yield:

methyl O--(S)-2-hydroxy-3-phenylpropanoate (131066-56-3) → C24H31N2O8P

Guidance literature:

Multi-step reaction with 3 steps

1: H₂ / 5percent Pd/C / ethyl acetate / 5 h

2: Et₃N, 4-A molecular sieves / CH₂Cl₂ / 48 h

3: aq. LiOH / tetrahydrofuran / 24 h

With lithium hydroxide; 4 A molecular sieve; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate;

DOI:10.1021/ja00001a043

upstream raw materials:

Z-Leu-OH

(S)-methyl 2-hydroxy-3-phenylpropanoate

Downstream raw materials:

methyl O-<<<(carbobenzoxyamino)methyl>methoxyphosphinyl>-L-leucyl>-(S)-2-hydroxy-3-phenylpropanoate