2-(4-aminophenyl)-4-(2-difluoromethylbenzimidazol-1-yl)-6-morpholinopyrimidine

Base Information

Chemical Name:2-(4-aminophenyl)-4-(2-difluoromethylbenzimidazol-1-yl)-6-morpholinopyrimidine
CAS No.:1010697-20-7
Molecular Formula:C₂₂H₂₀F₂N₆O
Molecular Weight:422.437
Hs Code.:

Synonyms:2-(4-aminophenyl)-4-(2-difluoromethylbenzimidazol-1-yl)-6-morpholinopyrimidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(4-aminophenyl)-4-(2-difluoromethylbenzimidazol-1-yl)-6-morpholinopyrimidine

Chemical Property:

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Technology Process of 2-(4-aminophenyl)-4-(2-difluoromethylbenzimidazol-1-yl)-6-morpholinopyrimidine

There total 2 articles about 2-(4-aminophenyl)-4-(2-difluoromethylbenzimidazol-1-yl)-6-morpholinopyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1010697-22-9
1-(2-chloro-6-morpholin-4-yl-pyrimidin-4-yl)-2-(difluoromethyl)benzoimidazole

: 214360-73-3
4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline

: 1010697-20-7
2-(4-aminophenyl)-4-(2-difluoromethylbenzimidazol-1-yl)-6-morpholinopyrimidine

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 110 ℃; for 0.5h; Product distribution / selectivity; Sealed tube; Microwave irradiation;

Reference yield:

: 110-91-8,99108-56-2
morpholine

: 1010697-28-5
N-[2-[[2-(4-aminophenyl)-6-chloro-pyrimidin-4-yl]amino]phenyl]-2,2-difluoro-acetamide

: 1010697-20-7
2-(4-aminophenyl)-4-(2-difluoromethylbenzimidazol-1-yl)-6-morpholinopyrimidine

Guidance literature:: In N,N-dimethyl acetamide; at 200 ℃; for 1.75h; Product distribution / selectivity; Sealed vessel; Microwave irradiation;

Reference yield:

: 4530-20-5
BOC-glycine

: 1010697-20-7
2-(4-aminophenyl)-4-(2-difluoromethylbenzimidazol-1-yl)-6-morpholinopyrimidine

: 2-{4-[N-(N-tert-butoxycarbonylglycyl)amino]phenyl}-4-(2-difluoromethylbenzimidazol-1-yl)-6-morpholinopyrimidine

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 66h;