(1S,2S)-1,2-di(p-bromobenzoyloxy)-1-(3--4-methoxyphenyl)-2-(3',4',5'-trimethoxyphenyl)ethane

Base Information

• Chemical Name: (1S,2S)-1,2-di(p-bromobenzoyloxy)-1-(3--4-methoxyphenyl)-2-(3',4',5'-trimethoxyphenyl)ethane
• CAS No.: 226990-01-8
• Molecular Formula: C₃₈H₄₂Br₂O₉Si
• Molecular Weight: 830.64
• Mol file: 226990-01-8.mol

Synonyms:(1S,2S)-1,2-di(p-bromobenzoyloxy)-1-(3--4-methoxyphenyl)-2-(3',4',5'-trimethoxyphenyl)ethane

Chemical Property of (1S,2S)-1,2-di(p-bromobenzoyloxy)-1-(3--4-methoxyphenyl)-2-(3',4',5'-trimethoxyphenyl)ethane

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (1S,2S)-1,2-di(p-bromobenzoyloxy)-1-(3--4-methoxyphenyl)-2-(3',4',5'-trimethoxyphenyl)ethane

There total 2 articles about (1S,2S)-1,2-di(p-bromobenzoyloxy)-1-(3--4-methoxyphenyl)-2-(3',4',5'-trimethoxyphenyl)ethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4-chlorobenzoyl chloride (586-75-4) + (1S,2S)-1-[3-(tert-Butyl-dimethyl-silanyloxy)-4-methoxy-phenyl]-2-(3,4,5-trimethoxy-phenyl)-ethane-1,2-diol (226989-87-3) → (1S,2S)-1,2-di(p-bromobenzoyloxy)-1-(3--4-methoxyphenyl)-2-(3',4',5'-trimethoxyphenyl)ethane (226990-01-8)

Guidance literature:

With pyridine; In N,N-dimethyl-formamide; a) RT, 4 h, b) from 45 deg C to 85 deg C, 16 h;

DOI:10.1021/jm9807149

Reference yield:

(E)-1-(3',4',5'-Trimethoxyphenyl)-2-(4''-methoxy-3''-tert-butyldimethylsiloxyphenyl)ethene (121042-96-4) → (1S,2S)-1,2-di(p-bromobenzoyloxy)-1-(3--4-methoxyphenyl)-2-(3',4',5'-trimethoxyphenyl)ethane (226990-01-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / methanesulfonamide / butan-1-ol; H2O / 72 h / AD mix-α

2: 93 percent / pyridine / dimethylformamide / a) RT, 4 h, b) from 45 deg C to 85 deg C, 16 h

With pyridine; methanesulfonamide; In water; N,N-dimethyl-formamide; butan-1-ol;

DOI:10.1021/jm9807149

Reference yield: 73.0%

(1S,2S)-1,2-di(p-bromobenzoyloxy)-1-(3--4-methoxyphenyl)-2-(3',4',5'-trimethoxyphenyl)ethane (226990-01-8) → (1S,2S)-1,2-di(p-bromobenzoyloxy)-1-(3-hydroxy-4-methoxyphenyl)-2-(3',4',5'-trimethoxyphenyl)ethane

Guidance literature:

With tetrabutyl ammonium fluoride; for 0.5h;

DOI:10.1021/jm9807149

upstream raw materials:

4-chlorobenzoyl chloride

(1S,2S)-1-[3-(tert-Butyl-dimethyl-silanyloxy)-4-methoxy-phenyl]-2-(3,4,5-trimethoxy-phenyl)-ethane-1,2-diol

(E)-1-(3',4',5'-Trimethoxyphenyl)-2-(4''-methoxy-3''-tert-butyldimethylsiloxyphenyl)ethene