N-[2-(2-thienyl)ethyl]-N-[(3-nitrophenyl)sulfonyl]glycine

Base Information

• Chemical Name: N-[2-(2-thienyl)ethyl]-N-[(3-nitrophenyl)sulfonyl]glycine
• CAS No.: 1377923-99-3
• Molecular Formula: C₁₄H₁₄N₂O₆S₂
• Molecular Weight: 370.407
• Mol file: 1377923-99-3.mol

Synonyms:N-[2-(2-thienyl)ethyl]-N-[(3-nitrophenyl)sulfonyl]glycine

Chemical Property of N-[2-(2-thienyl)ethyl]-N-[(3-nitrophenyl)sulfonyl]glycine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[2-(2-thienyl)ethyl]-N-[(3-nitrophenyl)sulfonyl]glycine

There total 3 articles about N-[2-(2-thienyl)ethyl]-N-[(3-nitrophenyl)sulfonyl]glycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

N-[2-(2-thienyl)ethyl]-N-[(3-nitrophenyl)sulfonyl]glycine methyl ester (1377924-50-9) → N-[2-(2-thienyl)ethyl]-N-[(3-nitrophenyl)sulfonyl]glycine (1377923-99-3)

Guidance literature:

N-[2-(2-thienyl)ethyl]-N-[(3-nitrophenyl)sulfonyl]glycine methyl ester; With sodium hydroxide; In methanol; for 1h; Reflux;

With hydrogenchloride; In water; at 20 ℃; pH=2;

DOI:10.1016/j.ejmech.2012.02.045

Reference yield:

N-[2-(2-thienyl)ethyl]-3-nitrobenzenesulfonamide (321711-62-0) → N-[2-(2-thienyl)ethyl]-N-[(3-nitrophenyl)sulfonyl]glycine (1377923-99-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2.1: sodium hydroxide / methanol / 1 h / Reflux

2.2: 20 °C / pH 2

With potassium carbonate; sodium hydroxide; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2012.02.045

Reference yield:

3-nitrobenzenesulphonyl chloride (121-51-7) → N-[2-(2-thienyl)ethyl]-N-[(3-nitrophenyl)sulfonyl]glycine (1377923-99-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 0 - 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

3.1: sodium hydroxide / methanol / 1 h / Reflux

3.2: 20 °C / pH 2

With potassium carbonate; triethylamine; sodium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2012.02.045

upstream raw materials:

N-[2-(2-thienyl)ethyl]-3-nitrobenzenesulfonamide

N-[2-(2-thienyl)ethyl]-N-[(3-nitrophenyl)sulfonyl]glycine methyl ester

3-nitrobenzenesulphonyl chloride