C₁₂H₁₀F₃N₃O

Base Information

• Chemical Name: C₁₂H₁₀F₃N₃O
• CAS No.: 1373886-86-2
• Molecular Formula: C₁₂H₁₀F₃N₃O
• Molecular Weight: 269.226
• Mol file: 1373886-86-2.mol

Synonyms:C₁₂H₁₀F₃N₃O

Chemical Property of C₁₂H₁₀F₃N₃O

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of C₁₂H₁₀F₃N₃O

There total 3 articles about C₁₂H₁₀F₃N₃O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

ethyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate (141573-95-7) + 4-fluoroaniline (371-40-4) → C12H10F3N3O (1373886-86-2)

Guidance literature:

With lithium hexamethyldisilazane; In N,N-dimethyl-formamide; at 40 ℃; for 0.0166667h; Flow reactor;

DOI:10.1002/anie.201704529

Reference yield:

C10H16F2N2O2Si → C12H10F3N3O (1373886-86-2)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid; tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 70 °C / Flow reactor

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane; N,N-dimethyl-formamide / 0.17 h / 120 °C / Flow reactor

3: lithium hexamethyldisilazane / N,N-dimethyl-formamide / 0.02 h / 40 °C / Flow reactor

With tetrabutyl ammonium fluoride; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/anie.201704529

Reference yield:

ethyl 3-(difluoromethyl)-1H-pyrazole-4-carboxylate (151733-96-9) → C12H10F3N3O (1373886-86-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane; N,N-dimethyl-formamide / 0.17 h / 120 °C / Flow reactor

2: lithium hexamethyldisilazane / N,N-dimethyl-formamide / 0.02 h / 40 °C / Flow reactor

With 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium hexamethyldisilazane; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/anie.201704529

upstream raw materials:

ethyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate

4-fluoroaniline

ethyl 3-(difluoromethyl)-1H-pyrazole-4-carboxylate