3-[[5-BROMO-3-METHOXY-2-(PHENYLMETHOXY)PHENYL]ACETYL]-4-(PHENYLMETHYL)-2-OXAZOLIDINONE

Base Information

Chemical Name:3-[[5-BROMO-3-METHOXY-2-(PHENYLMETHOXY)PHENYL]ACETYL]-4-(PHENYLMETHYL)-2-OXAZOLIDINONE
CAS No.:352019-95-5
Molecular Formula:C₂₆H₂₄BrNO₅
Molecular Weight:510.384
Hs Code.:
Mol file:352019-95-5.mol

Synonyms:(4S)-4-benzyl-3-[2-(2-benzyloxy-5-bromo-3-methoxyphenyl)acetyl]-2-oxazolidinone

Suppliers and Price of 3-[[5-BROMO-3-METHOXY-2-(PHENYLMETHOXY)PHENYL]ACETYL]-4-(PHENYLMETHYL)-2-OXAZOLIDINONE

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Chemical Property of 3-[[5-BROMO-3-METHOXY-2-(PHENYLMETHOXY)PHENYL]ACETYL]-4-(PHENYLMETHYL)-2-OXAZOLIDINONE

Chemical Property:

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Technology Process of 3-[[5-BROMO-3-METHOXY-2-(PHENYLMETHOXY)PHENYL]ACETYL]-4-(PHENYLMETHYL)-2-OXAZOLIDINONE

There total 6 articles about 3-[[5-BROMO-3-METHOXY-2-(PHENYLMETHOXY)PHENYL]ACETYL]-4-(PHENYLMETHYL)-2-OXAZOLIDINONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 90719-32-7
(S)-4-Benzyl-2-oxazolidinone

: (2-benzyloxy-5-bromo-3-methoxy-phenyl)-acetyl chloride

: 352019-95-5
(4S)-4-benzyl-3-[2-(2-benzyloxy-5-bromo-3-methoxyphenyl)acetyl]-2-oxazolidinone

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h;
DOI:10.1271/bbb.65.1134

Reference yield:

: 90-05-1
2-methoxy-phenol

: 352019-95-5
(4S)-4-benzyl-3-[2-(2-benzyloxy-5-bromo-3-methoxyphenyl)acetyl]-2-oxazolidinone

Guidance literature:: Multi-step reaction with 7 steps

1.1: 86 percent / Br₂ / CH₂Cl₂ / -78 - 20 °C

2.1: K₂CO₃ / acetonitrile / 12 h / Heating

2.2: 94 percent / 6 h / 190 °C

3.1: 81 percent / K₂CO₃ / acetonitrile / 12 h / 20 °C

4.1: aq. OsO₄; NaIO₄ / acetone / 5 h

5.1: 17.0 g / NaClO₂; aq. H₂O₂; NaH₂PO₄ / acetonitrile / 1 h / 10 °C

6.1: (COCl)2 / CH₂Cl₂ / 0 °C

7.1: 95 percent / n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

With sodium chlorite; sodium periodate; sodium dihydrogenphosphate; osmium(VIII) oxide; n-butyllithium; oxalyl dichloride; dihydrogen peroxide; bromine; potassium carbonate; In tetrahydrofuran; hexane; dichloromethane; acetone; acetonitrile; 2.2: Claisen rearrangement;
DOI:10.1271/bbb.65.1134

Reference yield:

: 352019-92-2
2-allyl-4-bromo-6-methoxyphenol

: 352019-95-5
(4S)-4-benzyl-3-[2-(2-benzyloxy-5-bromo-3-methoxyphenyl)acetyl]-2-oxazolidinone

Guidance literature:: Multi-step reaction with 5 steps

1: 81 percent / K₂CO₃ / acetonitrile / 12 h / 20 °C

2: aq. OsO₄; NaIO₄ / acetone / 5 h

3: 17.0 g / NaClO₂; aq. H₂O₂; NaH₂PO₄ / acetonitrile / 1 h / 10 °C

4: (COCl)2 / CH₂Cl₂ / 0 °C

5: 95 percent / n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

With sodium chlorite; sodium periodate; sodium dihydrogenphosphate; osmium(VIII) oxide; n-butyllithium; oxalyl dichloride; dihydrogen peroxide; potassium carbonate; In tetrahydrofuran; hexane; dichloromethane; acetone; acetonitrile;
DOI:10.1271/bbb.65.1134