Boc-Lys(4-[1-{1-tert-butyl-3,3,5,5-tetraethylpiperazin-2-on-1-yloxy}ethyl]benzoyl)-Gly-OMe

Base Information

Chemical Name:Boc-Lys(4-[1-{1-tert-butyl-3,3,5,5-tetraethylpiperazin-2-on-1-yloxy}ethyl]benzoyl)-Gly-OMe
CAS No.:1295578-95-8
Molecular Formula:C₃₉H₆₅N₅O₈
Molecular Weight:731.974
Hs Code.:

Synonyms:Boc-Lys(4-[1-{1-tert-butyl-3,3,5,5-tetraethylpiperazin-2-on-1-yloxy}ethyl]benzoyl)-Gly-OMe

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Chemical Property of Boc-Lys(4-[1-{1-tert-butyl-3,3,5,5-tetraethylpiperazin-2-on-1-yloxy}ethyl]benzoyl)-Gly-OMe

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Technology Process of Boc-Lys(4-[1-{1-tert-butyl-3,3,5,5-tetraethylpiperazin-2-on-1-yloxy}ethyl]benzoyl)-Gly-OMe

There total 12 articles about Boc-Lys(4-[1-{1-tert-butyl-3,3,5,5-tetraethylpiperazin-2-on-1-yloxy}ethyl]benzoyl)-Gly-OMe which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1295579-03-1
4-[1-(1-tert-butyl-3,3,5,5-tetraethylpiperazin-2-on-4-yloxy)-ethyl]-benzoic acid

: 1295578-89-0
Boc-Lys-Gly-OMe*HCl

: 1295578-95-8
Boc-Lys(4-[1-{1-tert-butyl-3,3,5,5-tetraethylpiperazin-2-on-1-yloxy}ethyl]benzoyl)-Gly-OMe

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1039/c0ob01047b

Reference yield:

: 264280-09-3
N-tert-butyl-2-ethylbutane-1,2-diamine

: 1295578-95-8
Boc-Lys(4-[1-{1-tert-butyl-3,3,5,5-tetraethylpiperazin-2-on-1-yloxy}ethyl]benzoyl)-Gly-OMe

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydroxide / 18 h / 10 - 20 °C

2.1: peracetic acid; acetic acid / ethyl acetate / 16 h / 0 - 20 °C / Inert atmosphere

3.1: Cu(OTf)2; copper; 4,4'-di-tert-butyl-2,2'-bipyridine / benzene / 16 h / 75 °C / Inert atmosphere

4.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.33 h / -78 °C / Inert atmosphere

4.2: -78 - 20 °C

4.3: 20 °C

5.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; peracetic acid; Cu(OTf)2; tert.-butyl lithium; copper; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4,4'-di-tert-butyl-2,2'-bipyridine; potassium hydroxide; In tetrahydrofuran; dichloromethane; ethyl acetate; pentane; benzene;
DOI:10.1039/c0ob01047b

Reference yield:

: 1295579-01-9
4-[1-(4-bromophenyl)-ethoxy]-1-tert-butyl-3,3,5,5-tetraethylpiperazin-2-one

: 1295578-95-8
Boc-Lys(4-[1-{1-tert-butyl-3,3,5,5-tetraethylpiperazin-2-on-1-yloxy}ethyl]benzoyl)-Gly-OMe

Guidance literature:: Multi-step reaction with 2 steps

1.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.33 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C

1.3: 20 °C

2.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; tert.-butyl lithium; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; pentane;
DOI:10.1039/c0ob01047b