1-({4-(chloromethyl)-2-[(phenylmethoxy)methyl](1,3-dioxolan-2-yl)}methoxy)-4-methoxybenzene

Base Information

• Chemical Name: 1-({4-(chloromethyl)-2-[(phenylmethoxy)methyl](1,3-dioxolan-2-yl)}methoxy)-4-methoxybenzene
• CAS No.: 946570-43-0
• Molecular Formula: C₂₀H₂₃ClO₅
• Molecular Weight: 378.853

Synonyms:1-({4-(chloromethyl)-2-[(phenylmethoxy)methyl](1,3-dioxolan-2-yl)}methoxy)-4-methoxybenzene

Chemical Property of 1-({4-(chloromethyl)-2-[(phenylmethoxy)methyl](1,3-dioxolan-2-yl)}methoxy)-4-methoxybenzene

Chemical Property:

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Technology Process of 1-({4-(chloromethyl)-2-[(phenylmethoxy)methyl](1,3-dioxolan-2-yl)}methoxy)-4-methoxybenzene

There total 3 articles about 1-({4-(chloromethyl)-2-[(phenylmethoxy)methyl](1,3-dioxolan-2-yl)}methoxy)-4-methoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

3-monochloro-1,2-propanediol (96-24-2) + 1-(benzyloxy)-3-(4-methoxyphenoxy)acetone (213828-28-5) → 1-({4-(chloromethyl)-2-[(phenylmethoxy)methyl](1,3-dioxolan-2-yl)}methoxy)-4-methoxybenzene (946570-43-0)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; for 16h; Heating;

DOI:10.1021/jm0702579

Reference yield:

2,3-epoxypropyl p-methoxyphenyl ether (2211-94-1,26744-15-0) → 1-({4-(chloromethyl)-2-[(phenylmethoxy)methyl](1,3-dioxolan-2-yl)}methoxy)-4-methoxybenzene (946570-43-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaH / Heating

1.2: pyridinium chlorochromate; 4 Angstroem molecular sieves / CH₂Cl₂

2.1: 68 percent / p-toluenesulfonic acid*H₂O / benzene / 16 h / Heating

With sodium hydride; toluene-4-sulfonic acid; In benzene;

DOI:10.1021/jm0702579

Reference yield:

benzyl alcohol (100-51-6,185532-71-2) → 1-({4-(chloromethyl)-2-[(phenylmethoxy)methyl](1,3-dioxolan-2-yl)}methoxy)-4-methoxybenzene (946570-43-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaH / Heating

1.2: pyridinium chlorochromate; 4 Angstroem molecular sieves / CH₂Cl₂

2.1: 68 percent / p-toluenesulfonic acid*H₂O / benzene / 16 h / Heating

With sodium hydride; toluene-4-sulfonic acid; In benzene;

DOI:10.1021/jm0702579

upstream raw materials:

3-monochloro-1,2-propanediol

1-(benzyloxy)-3-(4-methoxyphenoxy)acetone

2,3-epoxypropyl p-methoxyphenyl ether

benzyl alcohol

Downstream raw materials:

{5-[5-methyl-3-(2-methylpropyl)hexylidene]-4-oxo-2-[(phenylmethoxy)methyl]-1,3-dioxolan-2-yl}methyl 3-methylbutanoate

{5-[5-methyl-3-(2-methylpropyl)hexylidene]-4-oxo-2-[(phenylmethoxy)methyl]-1,3-dioxolan-2-yl}methyl 2,2-dimethylpropanoate

2-(hydroxymethyl)-5-[5-methyl-3-(2-methylpropyl)hexylidene]-2-[(phenylmethoxy)methyl]-1,3-dioxolan-4-one

2-(hydroxymethyl)-5-(3-methylbutylidene)-2-[(phenylmethoxy)methyl]-1,3-dioxolan-4-one

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