Technology Process of Fenclofenac
There total 24 articles about Fenclofenac which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
potassium hydroxide; 5,5-dimethyl-1,3-cyclohexadiene; water;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 80 percent / triethylamine / acetone / 1 h / Heating
2: 82 percent / H2 / 10percent Pd/C / ethyl acetate / 760 Torr
3: 1.) sodium nitrite, concd. H2SO4, 2.) cuprous chloride, concd. HCl / 1.) acetic acid, 0 deg C, 2.) acetic acid, a) from 5 deg C to RT, 1 h, b) 80 deg C, 30 min
With
hydrogenchloride; sulfuric acid; hydrogen; triethylamine; copper(l) chloride; sodium nitrite;
palladium on activated charcoal;
In
ethyl acetate; acetone;
DOI:10.1021/jm00364a004
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 80 percent / triethylamine / acetone / 1 h / Heating
2: 82 percent / H2 / 10percent Pd/C / ethyl acetate / 760 Torr
3: 1.) sodium nitrite, concd. H2SO4, 2.) cuprous chloride, concd. HCl / 1.) acetic acid, 0 deg C, 2.) acetic acid, a) from 5 deg C to RT, 1 h, b) 80 deg C, 30 min
With
hydrogenchloride; sulfuric acid; hydrogen; triethylamine; copper(l) chloride; sodium nitrite;
palladium on activated charcoal;
In
ethyl acetate; acetone;
DOI:10.1021/jm00364a004
