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CAS No.: | 25046-79-1 |
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Name: | glisoxepide |
Article Data: | 5 |
Molecular Structure: | |
Formula: | C20H27 N5 O5 S |
Molecular Weight: | 449.531 |
Synonyms: | Urea,1-(hexahydro-1H-azepin-1-yl)-3-[[p-[2-(5-methyl-3-isoxazolecarboxamido)ethyl]phenyl]sulfonyl]-(8CI); 4-[4-[b-(5-Methylisoxazole-3-carboxamido)ethyl]phenylsulfonyl]-1,1-hexamethylenesemicarbazide;BS 4231; Glisepin; Glisoxepid; Glisoxepide; Pro-Diaban; Pro-Diaben; RP 22410 |
Density: | 1.37g/cm3 |
Melting Point: | 189° |
Boiling Point: | °Cat760mmHg |
Flash Point: | °C |
Safety: | Poison by intravenous route. When heated to decomposition it emits very toxic fumes of NOx and SOx. Used as an antidiabetic agent. |
PSA: | 142.02000 |
LogP: | 3.92580 |
IUPAC Name: N-[2-[4-(Azepan-1-ylcarbamoylsulfamoyl)phenyl]ethyl]-5-methyl-1,2-oxazole-3-carboxamide
Synonyms of Pro-Diaban (CAS NO.25046-79-1) : 1-(Hexahydro-1H-azepin-1-yl)-3-[[p-[2-(5-methyl-3-isoxazolecarboxamido)ethyl]phenyl]sulfonyl]urea ; 3-Isoxazolecarboxamide, N-[2-[4-[[[[(hexahydro-1H-azepin-1-yl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-5-methyl- ; 4-[4-[b-(5-Methylisoxazole-3-carboxamido)ethyl]phenylsulfonyl]-1,1-hexamethylenesemicarbazide ; N-{2-[4-({[(Azepan-1-ylamino)carbonyl]amino}sulfonyl)phenyl]ethyl}-5-methylisoxazole-3-carboxamide
InChI:InChI=1/C20H27N5O5S/c1-15-14-18(23-30-15)19(26)21-11-10-16-6-8-17(9-7-16)31(28,29)24-20(27)22-25-12-4-2-3-5-13-25/h6-9,14H,2-5,10-13H2,1H3,(H,21,26)(H2,22,24,27)
CAS NO:25046-79-1
Molecular Formula:C20H27N5O5S
Molecular Weight :449.5239
Molecular Structure :
EINECS: 246-579-5
Index of Refraction:1.617
Surface Tension: 67.2 dyne/cm
Density: 1.37 g/cm3
Pro-Diaban (CAS NO.25046-79-1) is used as oral blood glucose lowering drugs.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
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cat | LD50 | oral | > 4gm/kg (4000mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 409, 1974. | |
dog | LD50 | oral | > 2gm/kg (2000mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 409, 1974. | |
mouse | LD50 | intravenous | 283mg/kg (283mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 409, 1974. |
mouse | LD50 | oral | > 10gm/kg (10000mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 409, 1974. | |
rabbit | LD50 | oral | > 4gm/kg (4000mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 409, 1974. | |
rat | LD50 | intravenous | 196mg/kg (196mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 409, 1974. |
rat | LD50 | oral | > 10gm/kg (10000mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 409, 1974. |
Poison by intravenous route. When Pro-Diaban (CAS NO.25046-79-1) is heated to decomposition, it emits very toxic fumes of NOx and SOx. Used as an antidiabetic agent.