1-[(2,3-dichlorophenyl)methyl]-4-fluoro-2-methyl-6-(4-morpholinyl)-1H-benzimidazole

Base Information

Chemical Name:1-[(2,3-dichlorophenyl)methyl]-4-fluoro-2-methyl-6-(4-morpholinyl)-1H-benzimidazole
CAS No.:1372540-00-5
Molecular Formula:C₁₉H₁₈Cl₂FN₃O
Molecular Weight:394.276
Hs Code.:

Synonyms:1-[(2,3-dichlorophenyl)methyl]-4-fluoro-2-methyl-6-(4-morpholinyl)-1H-benzimidazole

Suppliers and Price of 1-[(2,3-dichlorophenyl)methyl]-4-fluoro-2-methyl-6-(4-morpholinyl)-1H-benzimidazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-[(2,3-dichlorophenyl)methyl]-4-fluoro-2-methyl-6-(4-morpholinyl)-1H-benzimidazole

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-[(2,3-dichlorophenyl)methyl]-4-fluoro-2-methyl-6-(4-morpholinyl)-1H-benzimidazole

There total 7 articles about 1-[(2,3-dichlorophenyl)methyl]-4-fluoro-2-methyl-6-(4-morpholinyl)-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1372539-83-7
1-[(2,3-dichlorophenyl)methyl]-2-methyl-6-(4-morpholinyl)-1H-benzimidazol-4-amine

: 1372540-00-5
1-[(2,3-dichlorophenyl)methyl]-4-fluoro-2-methyl-6-(4-morpholinyl)-1H-benzimidazole

Guidance literature:: 1-[(2,3-dichlorophenyl)methyl]-2-methyl-6-(4-morpholinyl)-1H-benzimidazol-4-amine; With pyridine hydrofluoride; sodium nitrite; at -50 - 70 ℃; for 1.5h;

With sodium carbonate; In water; at 20 ℃;

Reference yield:

: 1372539-84-8
6-bromo-1-(2,3-dichlorobenzyl)-2-methyl-4-nitro-1H-benzo[d]imidazole

: 1372540-00-5
1-[(2,3-dichlorophenyl)methyl]-4-fluoro-2-methyl-6-(4-morpholinyl)-1H-benzimidazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 1,4-dioxane / 3 h / 80 °C / Inert atmosphere

2.1: water; iron(II) sulfate; iron / ethanol / 3 h / Reflux

3.1: sodium nitrite; pyridine hydrofluoride / 1.5 h / -50 - 70 °C

3.2: 20 °C

With pyridine hydrofluoride; water; iron; caesium carbonate; iron(II) sulfate; sodium nitrite; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In 1,4-dioxane; ethanol;

Reference yield:

: 606-22-4
2,6-dinitroaniline

: 1372540-00-5
1-[(2,3-dichlorophenyl)methyl]-4-fluoro-2-methyl-6-(4-morpholinyl)-1H-benzimidazole

Guidance literature:: Multi-step reaction with 7 steps

1.1: bromine / acetic acid / 2 h / 120 °C

2.1: diammonium sulfide / ethanol / 2 h / 90 °C

3.1: ethanol; water / 3 h / Reflux

4.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 80 °C

5.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 1,4-dioxane / 3 h / 80 °C / Inert atmosphere

6.1: water; iron(II) sulfate; iron / ethanol / 3 h / Reflux

7.1: sodium nitrite; pyridine hydrofluoride / 1.5 h / -50 - 70 °C

7.2: 20 °C

With diammonium sulfide; pyridine hydrofluoride; water; bromine; iron; potassium carbonate; caesium carbonate; iron(II) sulfate; sodium nitrite; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In 1,4-dioxane; ethanol; water; acetic acid; N,N-dimethyl-formamide;