dibenzyl 1-((4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]-pyrimidin-3(4H)-yl)-2-methoxyphenoxy)methyl)-3,3-difluorocyclobutyl phosphate

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Chemical Name:dibenzyl 1-((4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]-pyrimidin-3(4H)-yl)-2-methoxyphenoxy)methyl)-3,3-difluorocyclobutyl phosphate
CAS No.:1197420-29-3
Molecular Formula:C₃₈H₃₂ClF₂N₂O₇PS
Molecular Weight:765.171
Hs Code.:

Synonyms:dibenzyl 1-((4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]-pyrimidin-3(4H)-yl)-2-methoxyphenoxy)methyl)-3,3-difluorocyclobutyl phosphate

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Chemical Property of dibenzyl 1-((4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]-pyrimidin-3(4H)-yl)-2-methoxyphenoxy)methyl)-3,3-difluorocyclobutyl phosphate

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Technology Process of dibenzyl 1-((4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]-pyrimidin-3(4H)-yl)-2-methoxyphenoxy)methyl)-3,3-difluorocyclobutyl phosphate

There total 9 articles about dibenzyl 1-((4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]-pyrimidin-3(4H)-yl)-2-methoxyphenoxy)methyl)-3,3-difluorocyclobutyl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1197420-11-3
6-(4-chlorophenyl)-3-(4-((3,3-difluoro-1-hydroxycyclobutyl)methoxy)-3-methoxyphenyl)thieno[3,2-d]-pyrimidin-4(3H)-one

: 108549-23-1
Dibenzyl N,N-diisopropylphosphoramidite

: 1197420-29-3
dibenzyl 1-((4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]-pyrimidin-3(4H)-yl)-2-methoxyphenoxy)methyl)-3,3-difluorocyclobutyl phosphate

Guidance literature:: 6-(4-chlorophenyl)-3-(4-((3,3-difluoro-1-hydroxycyclobutyl)methoxy)-3-methoxyphenyl)thieno[3,2-d]-pyrimidin-4(3H)-one; Dibenzyl N,N-diisopropylphosphoramidite; With 1,2,4-Triazole; In 1,2-dichloro-ethane; for 1h; Reflux;

With dihydrogen peroxide; In water; 1,2-dichloro-ethane; at 15 - 45 ℃; for 0.416667h;
DOI:10.1021/acs.jmedchem.6b00676

Reference yield:

: 1197420-23-7
1-(3,3-difluorocyclobutyl)-N,N-dimethylmethanamine oxide

: 1197420-29-3
dibenzyl 1-((4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]-pyrimidin-3(4H)-yl)-2-methoxyphenoxy)methyl)-3,3-difluorocyclobutyl phosphate

Guidance literature:: Multi-step reaction with 6 steps

1.1: water / 165 °C

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C / Cooling with ice

3.1: sodium dihydrogen phosphate monohydrate / water; acetonitrile / 3.5 h / 130 °C

4.1: palladium 10% on activated carbon; hydrogen / methanol / 1.5 h / 2585.81 Torr

5.1: phenol / 0.75 h / 135 - 140 °C

6.1: 1,2,4-Triazole / 1,2-dichloro-ethane / 1 h / Reflux

6.2: 0.42 h / 15 - 45 °C

With 1,2,4-Triazole; sodium dihydrogen phosphate monohydrate; palladium 10% on activated carbon; hydrogen; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane; water; 1,2-dichloro-ethane; acetonitrile; phenol; 1.1: |Cope Elimination;
DOI:10.1021/acs.jmedchem.6b00676

Reference yield:

: 110654-33-6
1,1-difluoro-3-methylenecyclobutane

: 1197420-29-3
dibenzyl 1-((4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]-pyrimidin-3(4H)-yl)-2-methoxyphenoxy)methyl)-3,3-difluorocyclobutyl phosphate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C / Cooling with ice

2.1: sodium dihydrogen phosphate monohydrate / water; acetonitrile / 3.5 h / 130 °C

3.1: palladium 10% on activated carbon; hydrogen / methanol / 1.5 h / 2585.81 Torr

4.1: phenol / 0.75 h / 135 - 140 °C

5.1: 1,2,4-Triazole / 1,2-dichloro-ethane / 1 h / Reflux

5.2: 0.42 h / 15 - 45 °C

With 1,2,4-Triazole; sodium dihydrogen phosphate monohydrate; palladium 10% on activated carbon; hydrogen; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane; water; 1,2-dichloro-ethane; acetonitrile; phenol;
DOI:10.1021/acs.jmedchem.6b00676