110654-33-6

Basic information

• Product Name: 1,1-difluoro-3-methylenecyclobutane
• CAS NO: 110654-33-6
• Molecular Weight: 104.099
• Mol File: 110654-33-6.mol

Chemical Properties

• CAS DataBase Reference: 1,1-difluoro-3-methylenecyclobutane(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1-difluoro-3-methylenecyclobutane(110654-33-6)
• EPA Substance Registry System: 1,1-difluoro-3-methylenecyclobutane(110654-33-6)

Safety Data

• Hazardous Substances Data: 110654-33-6(Hazardous Substances Data)

Usage

Physical state

Colorless liquid

Odor

Pungent

Structure

Cyclobutane derivative with a methylene group and two fluorine atoms attached to the carbon ring

Usage

Building block in organic synthesis

Industries

Pharmaceutical and agrochemical

Applications

Synthesis of various organic compounds, development of new drugs and agricultural products

Intermediate

Useful in the production of specialty chemicals

Utilization

Manufacturing of advanced materials

Upstream product

• 186581-53-3 diazomethane 
• 29507-09-3 3,3-difluorocyclobutene 

Downstream Products

• 1099665-13-0 1-((4-amino-2-methoxyphenoxy)methyl)-3,3-difluorocyclobutanol 
• 1197420-25-9 3,3-difluoro-1-((2-methoxy-4-nitrophenoxy)methyl)cyclobutanol 
• 1197420-12-4 1-((4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)methyl)-3,3-difluorocyclobutyl dihydrogen phosphate 
• 1197420-29-3 dibenzyl 1-((4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]-pyrimidin-3(4H)-yl)-2-methoxyphenoxy)methyl)-3,3-difluorocyclobutyl phosphate 
• 1239489-42-9 C₃₁H₃₀ClF₂N₃O₇S 
• 1197420-13-5 1-((4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)methyl)-3,3-difluorocyclobutyl glycinate 
• 1197420-11-3 6-(4-chlorophenyl)-3-(4-((3,3-difluoro-1-hydroxycyclobutyl)methoxy)-3-methoxyphenyl)thieno[3,2-d]-pyrimidin-4(3H)-one 

Relevant articles and documents

THE THERMAL DEAZETATIONS OF FLUORINATED 2,3-DIAZABICYCLOHEPT-2-ENES

Thermal deazetation of difluoro- and tetrafluoro-2,3-diazabicyclohept-2-enes proceed via two parallel mechanistic pathways, one involving formation of a diradical via simple N2 loss, and the other proceeding via a retro-dipolar cycloaddition process.A key finding was the absence of isolation of a bicyclopentane product in the difluoro case.