7α-methoxy-7β-amino-3-chloro-3-cephem-4-carboxylic acid p-nitrobenzyl ester

Base Information

Chemical Name:7α-methoxy-7β-amino-3-chloro-3-cephem-4-carboxylic acid p-nitrobenzyl ester
CAS No.:115481-68-0
Molecular Formula:C₁₅H₁₄ClN₃O₆S
Molecular Weight:399.812
Hs Code.:

Synonyms:7α-methoxy-7β-amino-3-chloro-3-cephem-4-carboxylic acid p-nitrobenzyl ester

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Chemical Property of 7α-methoxy-7β-amino-3-chloro-3-cephem-4-carboxylic acid p-nitrobenzyl ester

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Technology Process of 7α-methoxy-7β-amino-3-chloro-3-cephem-4-carboxylic acid p-nitrobenzyl ester

There total 4 articles about 7α-methoxy-7β-amino-3-chloro-3-cephem-4-carboxylic acid p-nitrobenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 115481-67-9
(6R,7S)-3-Chloro-7-{[1-(3,5-di-tert-butyl-4-hydroxy-phenyl)-meth-(E)-ylidene]-amino}-7-methoxy-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester

: 115481-68-0
7α-methoxy-7β-amino-3-chloro-3-cephem-4-carboxylic acid p-nitrobenzyl ester

Guidance literature:: With girard's reagent T; In methanol; dichloromethane; for 2.5h; Ambient temperature;
DOI:10.1021/jm00118a024

Reference yield:

: 53994-83-5
(6R)-7t-amino-3-chloro-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester

: 115481-68-0
7α-methoxy-7β-amino-3-chloro-3-cephem-4-carboxylic acid p-nitrobenzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: benzene / 2 h / Heating

2: DDQ / benzene / 1 h / Ambient temperature; other reagent, solvent, temperature, reaction time

3: CH₂Cl₂ / 1 h / 0 °C

4: Girard's "T" reagent / CH₂Cl₂; methanol / 2.5 h / Ambient temperature

With girard's reagent T; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In methanol; dichloromethane; benzene;
DOI:10.1021/jm00118a024

Reference yield:

: 115463-71-3
(R)-3-Chloro-7-[(E)-3,5-di-tert-butyl-4-oxo-cyclohexa-2,5-dienylidenemethylimino]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester

: 115481-68-0
7α-methoxy-7β-amino-3-chloro-3-cephem-4-carboxylic acid p-nitrobenzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: CH₂Cl₂ / 1 h / 0 °C

2: Girard's "T" reagent / CH₂Cl₂; methanol / 2.5 h / Ambient temperature

With girard's reagent T; In methanol; dichloromethane;
DOI:10.1021/jm00118a024