7α-methoxy-7β-(thiopheneyl-2-acetamido)-3-chloro-3-cephem-4-carboxylic acid p-nitrobenzyl ester

Base Information

Chemical Name:7α-methoxy-7β-(thiopheneyl-2-acetamido)-3-chloro-3-cephem-4-carboxylic acid p-nitrobenzyl ester
CAS No.:115463-73-5
Molecular Formula:C₂₁H₁₈ClN₃O₇S₂
Molecular Weight:523.975
Hs Code.:

Synonyms:7α-methoxy-7β-(thiopheneyl-2-acetamido)-3-chloro-3-cephem-4-carboxylic acid p-nitrobenzyl ester

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Chemical Property of 7α-methoxy-7β-(thiopheneyl-2-acetamido)-3-chloro-3-cephem-4-carboxylic acid p-nitrobenzyl ester

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Technology Process of 7α-methoxy-7β-(thiopheneyl-2-acetamido)-3-chloro-3-cephem-4-carboxylic acid p-nitrobenzyl ester

There total 5 articles about 7α-methoxy-7β-(thiopheneyl-2-acetamido)-3-chloro-3-cephem-4-carboxylic acid p-nitrobenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 39098-97-0
2-thienylacetic acid chloride

: 115481-68-0
7α-methoxy-7β-amino-3-chloro-3-cephem-4-carboxylic acid p-nitrobenzyl ester

: 115463-73-5
7α-methoxy-7β-(thiopheneyl-2-acetamido)-3-chloro-3-cephem-4-carboxylic acid p-nitrobenzyl ester

Guidance literature:: With quinoline; In dichloromethane; at 0 ℃; for 90h;
DOI:10.1021/jm00118a024

Reference yield:

: 53994-83-5
(6R)-7t-amino-3-chloro-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester

: 115463-73-5
7α-methoxy-7β-(thiopheneyl-2-acetamido)-3-chloro-3-cephem-4-carboxylic acid p-nitrobenzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: benzene / 2 h / Heating

2: DDQ / benzene / 1 h / Ambient temperature; other reagent, solvent, temperature, reaction time

3: CH₂Cl₂ / 1 h / 0 °C

4: Girard's "T" reagent / CH₂Cl₂; methanol / 2.5 h / Ambient temperature

5: 20 percent / quinoline / CH₂Cl₂ / 90 h / 0 °C

With quinoline; girard's reagent T; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In methanol; dichloromethane; benzene;
DOI:10.1021/jm00118a024

Reference yield:

: 115463-71-3
(R)-3-Chloro-7-[(E)-3,5-di-tert-butyl-4-oxo-cyclohexa-2,5-dienylidenemethylimino]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester

: 115463-73-5
7α-methoxy-7β-(thiopheneyl-2-acetamido)-3-chloro-3-cephem-4-carboxylic acid p-nitrobenzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: CH₂Cl₂ / 1 h / 0 °C

2: Girard's "T" reagent / CH₂Cl₂; methanol / 2.5 h / Ambient temperature

3: 20 percent / quinoline / CH₂Cl₂ / 90 h / 0 °C

With quinoline; girard's reagent T; In methanol; dichloromethane;
DOI:10.1021/jm00118a024