methyl 2-<(tert-butoxycarbonyl)<(11-cyano-5-oxo-5H-dibenzocyclohepten-3-yl)methyl>amino>-3-nitrobenzoate

Base Information

Chemical Name:methyl 2-<(tert-butoxycarbonyl)<(11-cyano-5-oxo-5H-dibenzocyclohepten-3-yl)methyl>amino>-3-nitrobenzoate
CAS No.:169270-79-5
Molecular Formula:C₃₀H₂₅N₃O₇
Molecular Weight:539.544
Hs Code.:

methyl 2-<(tert-butoxycarbonyl)<(11-cyano-5-oxo-5H-dibenzo<a,d>cyclohepten-3-yl)methyl>amino>-3-nitrobenzoate

Synonyms:methyl 2-<(tert-butoxycarbonyl)<(11-cyano-5-oxo-5H-dibenzocyclohepten-3-yl)methyl>amino>-3-nitrobenzoate

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Chemical Property of methyl 2-<(tert-butoxycarbonyl)<(11-cyano-5-oxo-5H-dibenzocyclohepten-3-yl)methyl>amino>-3-nitrobenzoate

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Technology Process of methyl 2-<(tert-butoxycarbonyl)<(11-cyano-5-oxo-5H-dibenzocyclohepten-3-yl)methyl>amino>-3-nitrobenzoate

There total 9 articles about methyl 2-<(tert-butoxycarbonyl)<(11-cyano-5-oxo-5H-dibenzocyclohepten-3-yl)methyl>amino>-3-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 57113-90-3
methyl 2-(N-tert-butoxycarbonylamino)-3-nitrobenzoate

: 169270-61-5
7-(bromomethyl)-5-oxo-5H-dibenzocycloheptene-10-carbonitrile

: 169270-79-5
methyl 2-<(tert-butoxycarbonyl)<(11-cyano-5-oxo-5H-dibenzocyclohepten-3-yl)methyl>amino>-3-nitrobenzoate

Guidance literature:: With potassium carbonate; In acetonitrile; for 4h; Heating;
DOI:10.1021/jm00014a024

Reference yield:

: 2947-61-7
(4-methylphenyl)acetonitrile

: 169270-79-5
methyl 2-<(tert-butoxycarbonyl)<(11-cyano-5-oxo-5H-dibenzocyclohepten-3-yl)methyl>amino>-3-nitrobenzoate

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) NaOMe / 1.) MeOH, 20 min, 2.) MeOH, reflux, 1 h

2: 90.2 percent / NaBH₄ / propan-2-ol / 8 h / Heating

3: SOCl₂ / 1,2-dichloro-ethane / 1 h / Heating

4: AlCl₃ / 1,2-dichloro-ethane / 0.25 h / Heating

5: 1.) (TMS)2NLi / 1.) THF, -60 deg C, 10 min, 2.) THF, -70 deg C, 20 min

6: 92.4 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 0.5 h / Ambient temperature

7: N-bromosuccinimide, dibenzoyl peroxide / 1,2-dichloro-ethane / 2 h / Heating

8: 86 percent / K₂CO₃ / acetonitrile / 4 h / Heating

With sodium tetrahydroborate; N-Bromosuccinimide; aluminium trichloride; thionyl chloride; sodium methylate; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; dibenzoyl peroxide; In dichloromethane; 1,2-dichloro-ethane; isopropyl alcohol; acetonitrile;
DOI:10.1021/jm00014a024

Reference yield:

: 16859-59-9
3-hydroxy-1(3H)-isobenzofuranone

: 169270-79-5
methyl 2-<(tert-butoxycarbonyl)<(11-cyano-5-oxo-5H-dibenzocyclohepten-3-yl)methyl>amino>-3-nitrobenzoate

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) NaOMe / 1.) MeOH, 20 min, 2.) MeOH, reflux, 1 h

2: 90.2 percent / NaBH₄ / propan-2-ol / 8 h / Heating

3: SOCl₂ / 1,2-dichloro-ethane / 1 h / Heating

4: AlCl₃ / 1,2-dichloro-ethane / 0.25 h / Heating

5: 1.) (TMS)2NLi / 1.) THF, -60 deg C, 10 min, 2.) THF, -70 deg C, 20 min

6: 92.4 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 0.5 h / Ambient temperature

7: N-bromosuccinimide, dibenzoyl peroxide / 1,2-dichloro-ethane / 2 h / Heating

8: 86 percent / K₂CO₃ / acetonitrile / 4 h / Heating

With sodium tetrahydroborate; N-Bromosuccinimide; aluminium trichloride; thionyl chloride; sodium methylate; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; dibenzoyl peroxide; In dichloromethane; 1,2-dichloro-ethane; isopropyl alcohol; acetonitrile;
DOI:10.1021/jm00014a024