(E)-4-(4-Fluorophenyl)-3-(2-iodoethenyl)-2-(1-methylethyl)-6-phenylpyridin

Base Information

Chemical Name:(E)-4-(4-Fluorophenyl)-3-(2-iodoethenyl)-2-(1-methylethyl)-6-phenylpyridin
CAS No.:129122-55-0
Molecular Formula:C₂₂H₁₉FIN
Molecular Weight:443.302
Hs Code.:

Synonyms:(E)-4-(4-Fluorophenyl)-3-(2-iodoethenyl)-2-(1-methylethyl)-6-phenylpyridin

Suppliers and Price of (E)-4-(4-Fluorophenyl)-3-(2-iodoethenyl)-2-(1-methylethyl)-6-phenylpyridin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (E)-4-(4-Fluorophenyl)-3-(2-iodoethenyl)-2-(1-methylethyl)-6-phenylpyridin

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (E)-4-(4-Fluorophenyl)-3-(2-iodoethenyl)-2-(1-methylethyl)-6-phenylpyridin

There total 10 articles about (E)-4-(4-Fluorophenyl)-3-(2-iodoethenyl)-2-(1-methylethyl)-6-phenylpyridin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Bu₃ SnH: Bu₃ SnH

: 129122-42-5
3-ethynyl-4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenylpyridine

: 129122-55-0
(E)-4-(4-Fluorophenyl)-3-(2-iodoethenyl)-2-(1-methylethyl)-6-phenylpyridin

Guidance literature:: With I₂; azobisisobutyronitrile; SiO₂; In tri-n-butylstannyl hydride (Bu₃ SnH); hexane; sodium hydrogencarbonate; ethyl acetate;

Reference yield:

: 1608-51-1
4-fluorochalcone

: 129122-55-0
(E)-4-(4-Fluorophenyl)-3-(2-iodoethenyl)-2-(1-methylethyl)-6-phenylpyridin

Guidance literature:: Multi-step reaction with 7 steps

1: EtONa / ethanol / 4.5 h / Ambient temperature

2: NH₄OAc, Cu(OAc)2 / acetic acid / 24 h / Heating

3: LiAlH₄ / tetrahydrofuran / 6 h / Ambient temperature

4: 87 percent / Dess-Martin periodinane / CH₂Cl₂ / 0.5 h / Ambient temperature

5: triphenylphosphine / CH₂Cl₂ / 0.42 h / Ambient temperature

6: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

7: 1.) AIBN, tri-n-butyltin hydride, 2.) I₂ / 1.) 120 deg C - 140 deg C, 3 h, 2.) Et₂O, RT, 45 min

With lithium aluminium tetrahydride; n-butyllithium; copper diacetate; 2,2'-azobis(isobutyronitrile); ammonium acetate; iodine; tri-n-butyl-tin hydride; sodium ethanolate; Dess-Martin periodane; triphenylphosphine; In tetrahydrofuran; ethanol; hexane; dichloromethane; acetic acid;
DOI:10.1021/jm00113a019

Reference yield:

: 122253-00-3
4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinemethanol

: 129122-55-0
(E)-4-(4-Fluorophenyl)-3-(2-iodoethenyl)-2-(1-methylethyl)-6-phenylpyridin

Guidance literature:: Multi-step reaction with 4 steps

1: 87 percent / Dess-Martin periodinane / CH₂Cl₂ / 0.5 h / Ambient temperature

2: triphenylphosphine / CH₂Cl₂ / 0.42 h / Ambient temperature

3: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

4: 1.) AIBN, tri-n-butyltin hydride, 2.) I₂ / 1.) 120 deg C - 140 deg C, 3 h, 2.) Et₂O, RT, 45 min

With n-butyllithium; 2,2'-azobis(isobutyronitrile); iodine; tri-n-butyl-tin hydride; Dess-Martin periodane; triphenylphosphine; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jm00113a019