4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinemethanol

Base Information

• Chemical Name: 4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinemethanol
• CAS No.: 122253-00-3
• Molecular Formula: C₂₁H₂₀FNO
• Molecular Weight: 321.394
• Mol file: 122253-00-3.mol

Synonyms:4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinemethanol

Chemical Property of 4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinemethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinemethanol

There total 5 articles about 4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinecarboxylic acid, ethyl ester (122252-70-4) → 4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinemethanol (122253-00-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 1.5h; Ambient temperature;

DOI:10.1021/jm00163a010

Reference yield:

4-fluorochalcone (1608-51-1) → 4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinemethanol (122253-00-3)

Guidance literature:

Multi-step reaction with 3 steps

1: EtONa / ethanol / 4.5 h / Ambient temperature

2: NH₄OAc, Cu(OAc)2 / acetic acid / 24 h / Heating

3: LiAlH₄ / tetrahydrofuran / 6 h / Ambient temperature

With lithium aluminium tetrahydride; copper diacetate; ammonium acetate; sodium ethanolate; In tetrahydrofuran; ethanol; acetic acid;

DOI:10.1021/jm00113a019

Reference yield:

4-fluorobenzaldehyde (459-57-4) → 4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinemethanol (122253-00-3)

Guidance literature:

Multi-step reaction with 4 steps

1: EtONa / ethanol / 16 h / Ambient temperature

2: EtONa / ethanol / 4.5 h / Ambient temperature

3: NH₄OAc, Cu(OAc)2 / acetic acid / 24 h / Heating

4: LiAlH₄ / tetrahydrofuran / 6 h / Ambient temperature

With lithium aluminium tetrahydride; copper diacetate; ammonium acetate; sodium ethanolate; In tetrahydrofuran; ethanol; acetic acid;

DOI:10.1021/jm00113a019

upstream raw materials:

4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinecarboxylic acid, ethyl ester

4-fluorochalcone

4-fluorobenzaldehyde

acetophenone

Downstream raw materials:

3-Bromomethyl-4-(4-fluoro-phenyl)-2-isopropyl-6-phenyl-pyridine

4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinecarboxaldehyde

(4R,6S)-4-(tert-Butyl-diphenyl-silanyloxy)-6-{(E)-2-[4-(4-fluoro-phenyl)-2-isopropyl-6-phenyl-pyridin-3-yl]-vinyl}-tetrahydro-pyran-2-ol

(4R,6S)-4-(tert-Butyl-diphenyl-silanyloxy)-6-{(E)-2-[4-(4-fluoro-phenyl)-2-isopropyl-6-phenyl-pyridin-3-yl]-vinyl}-tetrahydro-pyran-2-one